Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00029)
  Official Symbol
HIST1H3A
  Official Full Name
histone cluster 1, H3a
  Synonym
H3.1;H3.f;H3/A;H3/b;H3/c;H3/d;H3/f;H3/h;H3/i;H3/j;H3/k;H3/l;H3F1K;H3FA;H3FB;H3FC;H3FD;H3FF;H3FH;H3FI;H3FJ;H3FK;H3FL
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:26020718 - End:26021186)
  Strand
+
  Uniprot Entry
P68431 
  ENSG ID
ENSG00000198366 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A20: Schizophrenia Schizophrenia [Schizophrenia]
            Detailed Information Disease Link click to show the detail information of this Disease
         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         LA02: Spina bifida Neural tube defects [Spina bifida]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors [Gastrointestinal stromal tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
H2S could induce H3K4me2 modification at specific promoters.
  Metabolite Name: Iso-butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [3]
     Description
isobutyrate couldincreased lysine isobutyrylation levels on histones H3 at lysine 14.
  Metabolite Name: Hydrogen peroxide (H2O2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4]
     Description
Hydrogen peroxide (H2O2) has been shown to trigger host signaling that culminates in H3S10 dephosphorylation.
  Metabolite Name: Hydrogen peroxide (H2O2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Hydrogen peroxide (H2O2) has been shown to increase histone methylation of histone H3K27 in BEAS-2B cells.
  Metabolite Name: Hydrogen peroxide (H2O2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Hydrogen peroxide (H2O2) has been shown to increase histone methylation of histone H3K4 in BEAS-2B cells.
  Metabolite Name: Hydrogen peroxide (H2O2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Hydrogen peroxide (H2O2) has been shown to decrease Histone Acetylation of histone H3K8 in BEAS-2B cells.
  Metabolite Name: Hydrogen peroxide (H2O2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Hydrogen peroxide (H2O2) has been shown to increase histone methylation of histone H3K9 in BEAS-2B cells.
  Metabolite Name: Ethionine
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [3]
     Description
Ethionine has been shown to decrease thelevels of H3K9me3 for Nang.
  Metabolite Name: Ethionine
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [3]
     Description
Ethionine has been shown to decrease thelevels of H3K9me3 for Tead4.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [7]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4ac at the promoter of P300.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [8]
     Description
Acetate has been shown to increase acetylation on histone H3 at Lysine 9.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [9]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [9]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4acat the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [9]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [9]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of ER-BETA.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [10]
     Description
Lipopolysaccharide has been shown to induce histone H3 acetylation.
  Metabolite Name: Ethionine
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [11]
     Description
Ethionine could reduce the histone 3-methylation at the Lysines 36.
  Metabolite Name: Spermine
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [12]
     Description
Spermine could increase the expression levels of Ac-Histone H3 in HT1080 cells.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Acetate could markedly enhanced H3K9 acetylation level at the promoter of LDHA.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [15]
     Description
Acetate could markedly enhanced H3K56 acetylation level at the promoter of ACACA.
  Metabolite Name: Ethionine
     Detailed Information Meta Info click to show the detail information of this Metabolite [16], [17]
     Description
Ethionine could reduce the histone 3-methylation at the Lysines 9.
  Metabolite Name: Folate (B9)
     Detailed Information Meta Info click to show the detail information of this Metabolite [16], [17]
     Description
Folate (B9) has been shown to decrease H3K27 methylation marks in the Hes1 gene promoters.
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3]
     Description
Propionate has been shown to result in the increase in histone H3 acetylation
  Metabolite Name: Sperimidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3]
     Description
Spermidine has been shown to reduce the acetylation levels of Lys 18 at histone H3 in human PBMC cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Benzoate has been shown to enhance the H3K18 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Benzoate has been shown to enhance the H3K9 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Benzoate has been shown to enhance the H3K23 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Benzoate has been shown to enhance the H3K14 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Benzoate has been shown to enhance the H3K4 benzoylation levels in HepG2 cells.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H3 at K18
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H3 at K4
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H3 at K9
  Metabolite Name: Folate (B9)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Folate (B9) has been shown to decrease H3K27 methylation marks in the Neurog2 gene promoters.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at AGRP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at ARNT2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at ASCL1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at AVP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at BMP7 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at CARTPT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at CCK loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at CORT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at CRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at GALP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at GAST loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at GHRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at GNRH2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at HCRT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at HMX2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at KISS1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at LHX1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at NKX2-1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at NPVF loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at NPW loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at NPY loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at NR5A1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at OTP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at OXT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at PDYN loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at PENK loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at PNOC loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at POMC loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at POU3F2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at PRLH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at RAX loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at SHH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at SIM1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at SIX3 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at SST loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at TRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Kynurenine has been shown to increase H3K4me3 at VAX1 loci.
  Metabolite Name: Niacin (B3)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Niacin (B3) could decrease H3K27 trimethylationat the FXN gene in friedreich's ataxia.
  Metabolite Name: Niacin (B3)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Niacin (B3) could decrease H3K9 trimethylationat the FXN gene in friedreich's ataxia.
  Metabolite Name: Niacin (B3)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Niacin (B3) could increase histone H3 acetylation at the FXN gene in friedreich's ataxia.
  Metabolite Name: Phenylbutyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
Phenylbutyrate has been shown to induce increased histones H3 acetylation in D283-MED cells.
  Metabolite Name: Riboflavin (B2)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [18]
     Description
RIboflavin (B2) has been shown to activate Lysine-specific demethylase 1 (LSD1) so that decrease the accumulation of H3K4me1.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Acetate could markedly enhanced H3K9 acetylation level at the promoter of ACACA.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Acetate could markedly enhanced H3K27 acetylation level at the promoter of FASN.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Acetate could markedly enhanced H3K56 acetylation level at the promoter of FASN.
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Butyrate has been shown to increase histone H3 acetylation at Foxo3A promoter.
  Metabolite Name: Phenylbutyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Phenylbutyrate has been shown to induce increased histones H3 acetylation in DAOY cells.
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Propionate has been shown to increase histone propionylation of histone 3 lysine 23 (H3K23) in Primary myocytes.
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [19]
     Description
Propionate has been shown to increase histone propionylation of histone 3 lysine 23 (H3K23) in C2C12 cells.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [20], [21]
     Description
Hydrogen sulfide (H2S) has been shown to increase H3K27 methylation at the IL-6 promoter.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [20], [21]
     Description
Hydrogen sulfide (H2S) has been shown to increase the methylation at lysine 9 of histone H3 at the IL-6 promoter.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [20], [21]
     Description
Hydrogen sulfide (H2S) has been shown to reduce the chromatin openness by decreasing histone H3 acetylation at the TNF-Alpha promoter.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [20], [21]
     Description
Hydrogen sulfide (H2S) has been shown to increase H3K27 methylation at TNF-Alpha promoters.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [20], [21]
     Description
Hydrogen sulfide (H2S) has been shown to increase the methylation at lysine 9 of histone H3 at the TNF-Alpha promoter.
  Metabolite Name: K3
     Detailed Information Meta Info click to show the detail information of this Metabolite [22], [23]
     Description
Vitamin K3 has been shown to associated with keratin 8 phosphorylation and histone H3 arylation at Cys110.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [24]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [25]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4acat the promoter of ER-BETA.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [25]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of ER-BETA.
  Metabolite Name: Flagellin
     Detailed Information Meta Info click to show the detail information of this Metabolite [26]
     Description
Legionella pneumophila time-dependently induced acetylation of Ac-Lys14-H3 at the IL-8 promoter depended on flagellin.
  Metabolite Name: Flagellin
     Detailed Information Meta Info click to show the detail information of this Metabolite [26]
     Description
Legionella pneumophila-induced phosphorylation of P-Ser10-H3 at the IL-8 promoter depended on flagellin.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [27]
     Description
a-ketoglutarate (a-KG) could decrease H3K9me3 abundance in the promoter regions of Bmp2 in aged mesenchymal stromal/stem cells.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Acetate could markedly enhanced H3K9 acetylation level at the promoter of FASN.
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Choline could increase the trimethylation of H3K27 in Liver.
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Choline could increase the trimethylation of H3K27 in Cortex.
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Choline could decrease the dimethylation of H3K4 in Liver.
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Choline could increase the dimethylation of H3K9 in Liver.
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [28]
     Description
Choline could increase the dimethylation of H3K9 in Cortex.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [30]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [30]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4acat the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of ER-BETA.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of ER-BETA.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of ER-BETA.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4acat the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K27me3at the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K27me3 at the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increaserepressive histone marks such as H3K4acat the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to increase repressive histone marks such as H3K4ac at the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reducerepressive histone marks such as H3K9me3at the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Equol has been shown to reduce repressive histone marks such as H3K9me3 at the promoter of SRC3.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [29], [31]
     Description
Lipopolysaccharide (LPS) could induce transient acetylation of histone H3 lysine 9 in oral epithelial cells through the pattern recognition receptor pathway.
  Metabolite Name: urolithin A
     Detailed Information Meta Info click to show the detail information of this Metabolite [32], [33]
     Description
urolithin A could enhance acetylations of Lys-9 residues of histone H3 within chromatin surrounding the promoter region of gp91-phox gene.
  Metabolite Name: Docosahexaenoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [32], [34]
     Description
docosahexaenoic acid (DHA) could reduced H3K27me3 levels.
  Metabolite Name: eicosapentaenoic acid (EPA)
     Detailed Information Meta Info click to show the detail information of this Metabolite [32], [34]
     Description
eicosapentaenoic acid (EPA) could reduced H3K27me3 levels.
  Metabolite Name: S-Adenosyl Methionine (SAM)
     Detailed Information Meta Info click to show the detail information of this Metabolite [35], [36]
     Description
S-Adenosyl Methionine (SAM) is the main methyl-donating substrate for DNMTs and HNMTs
  Metabolite Name: 2-Aminoacetophenone
     Detailed Information Meta Info click to show the detail information of this Metabolite [37]
     Description
2-Aminoacetophenone could reduce H3K18ac at TNF-alpha promoter.
  Metabolite Name: Hydrogen sulfide (H2S)
     Detailed Information Meta Info click to show the detail information of this Metabolite [38], [15]
     Description
Hydrogen sulfide (H2S) has been shown to reduce the chromatin openness by decreasing histone H3 acetylation at the IL-6 promoter.
  Metabolite Name: Inositol phosphate
     Detailed Information Meta Info click to show the detail information of this Metabolite [39], [40]
     Description
Inositol phosphate could be decreased H3K9Ac in the intestinal epithelial cells.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [39], [15]
     Description
a-ketoglutarate (a-KG) could decrease H3K27me3 abundance in the promoter regions of Bmp2 in aged mesenchymal stromal/stem cells.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [39], [15]
     Description
a-ketoglutarate (a-KG) could decrease H3K27me3 abundance in the promoter regions of Nanog in aged mesenchymal stromal/stem cells.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [39], [15]
     Description
a-ketoglutarate (a-KG) could decrease H3K9me3 abundance in the promoter regions of Nanog in aged mesenchymal stromal/stem cells.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [39], [15]
     Description
Acetate could upregulate theacetylation levels of H3K56 at LDHA promoter under hypoxia.
  Metabolite Name: Iso-butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [42]
     Description
isobutyrate couldincreased lysine isobutyrylation levels on histones H3 at lysine 23.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [43]
     Description
Acetate could markedly enhanced H3K27 acetylation level at the promoter of LDHA.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [15]
     Description
a-ketoglutarate (a-KG) could decrease H3K9me3 abundance in the promoter regions of Bmp2 in aged mesenchymal stromal/stem cells.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [15]
     Description
Acetate could markedly enhanced H3K27 acetylation level at the promoter of ACACA.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [15]
     Description
Acetate could upregulate theacetylation levels of H3K27 at VEGF promoter under hypoxia.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [15]
     Description
Acetate could upregulate theacetylation levels of H3K56 at VEGF promoter under hypoxia.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [41], [15]
     Description
Acetate could upregulate theacetylation levels of H3K9 at VEGF promoter under hypoxia.
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [45]
     Description
Butyrate has been shown to increase the abundances of acetylated H3K9ac.
  Metabolite Name: Taurocholate
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [42]
     Description
Taurocholate could increase the levels of citrullinated histone 3 in the pancreas.
  Metabolite Name: Iso-Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [46]
     Description
Isovalerate has been shown to increased bulk histone H3 acylation.
  Metabolite Name: Sperimidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [8]
     Description
Spermidine has been shown to reduce the acetylation levels of Lys 14 at histone H3 in human PBMC cells.
  Metabolite Name: a-Ketoglutarate(a-Kg)
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [15]
     Description
a-ketoglutarate (a-KG) could decrease H3K27me3 abundance in the promoter regions of Bmp4 in aged mesenchymal stromal/stem cells.
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [15]
     Description
Butyrate has been shown to increase the abundances of acetylated H3K9ac.
  Metabolite Name: Methionine
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [15]
     Description
Methionine supplementation could increase levels of H3K4me3 in brain.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [44], [15]
     Description
Valerate has been shown to result in the increase in histone H3 acetylation
  Metabolite Name: Spermidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [47], [11]
     Description
Spermidine could decrease the expression levels of Ac-Histone H3.
  Metabolite Name: S-Adenosyl Homocysteine (SAH)
     Detailed Information Meta Info click to show the detail information of this Metabolite [48], [49]
     Description
S-Adenosylhomocysteine (SAH) could induce changes in H3K4me3.
  Metabolite Name: Iso-Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [50]
     Description
Isovalerate has been shown to increased bulk histone H3 acylation.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K27Ac modification in the promoter region of EIF4eBP in human monocytes.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K4me3 modification in the promoter region of EIF4eBP in human monocytes.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K27Ac modification in the promoter region of hexokinase (HK1) in human monocytes.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K4me3 modification in the promoter region of hexokinase (HK1) in human monocytes.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K27Ac modification in the promoter region of pyruvate kinase (PKM) in human monocytes.
  Metabolite Name: beta-glucan
     Detailed Information Meta Info click to show the detail information of this Metabolite [51]
     Description
beta-glucan has been shown to increase the H3K4me3 modification in the promoter region of pyruvate kinase (PKM) in human monocytes.

Protein(s) with this epigenetic modification
  Protein Name: Pyruvate oxidase SpxB
     Detailed Information Pro Info click to show the detail information of this protein [4]
     Description
Pyruvate oxidase SpxB could be induce specific histone modifications
  Protein Name: HP0175
     Detailed Information Pro Info click to show the detail information of this protein [52]
     Description
HP0175 responsible for IL-6 expression could be correlated with phosphorylation of H3S10 at the IL-6 promoter.
  Protein Name: CagA
     Detailed Information Pro Info click to show the detail information of this protein [53]
     Description
Helicobacter pylori's pathogenicity island cagA could induce H3 Ser10 dephosphorylation in AGS cells.
  Protein Name: cagPAI
     Detailed Information Pro Info click to show the detail information of this protein [53]
     Description
Helicobacter pylori-induces histone H3 Ser10 dephosphorylation and cagPAI is responsible for this effect.
  Protein Name: vacA
     Detailed Information Pro Info click to show the detail information of this protein [53]
     Description
Helicobacter pylori's pathogenicity island vacA could induce H3 Ser10 dephosphorylation in AGS cells.
  Protein Name: Rv1988
     Detailed Information Pro Info click to show the detail information of this protein [54]
     Description
Rv1988 (Arginine methyltransferase) has been shown to dimethylate an arginine residue located to the core region of histone H3.
  Protein Name: RomA
     Detailed Information Pro Info click to show the detail information of this protein [55]
     Description
The Legionella pneumophila effector RomA trimethylates H3K14 has a main impact on the CXCL1 promoter region.
  Protein Name: RomA
     Detailed Information Pro Info click to show the detail information of this protein [55]
     Description
The type IV secreted effector RomA of Legionella pneumophila decreases H3K14 acetylation to repress host gene expression.
  Protein Name: RomA
     Detailed Information Pro Info click to show the detail information of this protein [55]
     Description
The Legionella pneumophila effector RomA trimethylates H3K14 has a main impact on the CXCL2 promoter region.
  Protein Name: LegAS4
     Detailed Information Pro Info click to show the detail information of this protein [56]
     Description
LegAS4 has been shown to tri-methylate histone H3 on lysine 14.
  Protein Name: Rv3423.1
     Detailed Information Pro Info click to show the detail information of this protein [57]
     Description
Rv3423.1 has been shown to generate euchromatic histone marks by acetylating histone H3 at lysine 9.
  Protein Name: Rv3423.1
     Detailed Information Pro Info click to show the detail information of this protein [57]
     Description
Rv3423.1 has been shown to generate euchromatic histone marks by acetylating histone H3 at lysine 14.
  Protein Name: Ankyrin A
     Detailed Information Pro Info click to show the detail information of this protein [58]
     Description
Ankyrin A (AnkA) could be decrease the level of histone H3 acetylation at the CYBB locus, particularly around AnkA binding sites.
  Protein Name: cagPAI
     Detailed Information Pro Info click to show the detail information of this protein [59]
     Description
Helicobacter pylori decreases acetylation of Lys23 of histone H3 dependent on genes present on its pathogenicity island cagPAI.
  Protein Name: CpnSET
     Detailed Information Pro Info click to show the detail information of this protein [59]
     Description
CpnSET has been shown to methylate mouse histone H3 in vitro.
  Protein Name: RomA
     Detailed Information Pro Info click to show the detail information of this protein [59]
     Description
RomA has been shown to specifically methylate lysine 14 of the histone H3 (H3K14).
  Protein Name: BbSET
     Detailed Information Pro Info click to show the detail information of this protein [59], [60]
     Description
BbSET could be have methyltransferase activity like LegAS4, and Lys4 of histone H3 (H3K4) as its target.
  Protein Name: LegAS4
     Detailed Information Pro Info click to show the detail information of this protein [59], [60]
     Description
LegAS4 has methyltransferase activity like RomA, while Lys4 of histone H3 (H3K4) as its target.
  Protein Name: BtSET
     Detailed Information Pro Info click to show the detail information of this protein [60]
     Description
BtSET (Histone lysine methyltransferase) has been shown to promote H3K4 methylation of rDNA chromatin
  Protein Name: LntA
     Detailed Information Pro Info click to show the detail information of this protein [61]
     Description
LntA can inhibit the binding of the chromatin suppressor BAHD1 of epithelial cells to histone H3 on the promoter of interferon (IFN) stimulated genes
  Protein Name: NuE
     Detailed Information Pro Info click to show the detail information of this protein [62]
     Description
NuE could methylates H3.
  Protein Name: OspF
     Detailed Information Pro Info click to show the detail information of this protein [63]
     Description
OspF has been shown to strongly repressed accumulation of histone H3 phosphorylated at Ser10 at the IL8 promoter.
  Protein Name: CagA
     Detailed Information Pro Info click to show the detail information of this protein [64]
     Description
The cytotoxin-associated gene A (CagA) of Helicobacter pylori enhances EZH2 expression, leading to increased H3K27 trimethylation.
  Protein Name: InIB
     Detailed Information Pro Info click to show the detail information of this protein [65]
     Description
InlB can deacetylates histone H3 on lysine 18 (H3K18) and the ctivity of SIRT2 on H3K18 is important for infection in vivo.
  Protein Name: InlB
     Detailed Information Pro Info click to show the detail information of this protein [65]
     Description
The bacterial factor InlB of the bacterium Listeria monocytogenes could influence the process of deacetylates histone H3 on lysine 18 (H3K18).
  Protein Name: InlB
     Detailed Information Pro Info click to show the detail information of this protein [65]
     Description
The bacterial factor InlB of the bacterium Listeria innocua could influence the process of deacetylates histone H3 on lysine 18 (H3K18).
  Protein Name: Alpha-hemolysin
     Detailed Information Pro Info click to show the detail information of this protein [66]
     Description
hlyA could significantly decrease the acetyl-CoA level, leading to reduced H3K9 histone acetylation in the promotor region of CXCL8.
  Protein Name: Lethal toxin
     Detailed Information Pro Info click to show the detail information of this protein [67]
     Description
Lethal toxin has been shown to impair histone H3K14 acetylation and IL-8 and KC promoter accessibility.
  Protein Name: Lethal toxin
     Detailed Information Pro Info click to show the detail information of this protein [67]
     Description
Lethal toxin has been shown to impair histone H3S10 phosphorylation and IL-8 and KC promoter accessibility.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Listeriolysin O(LLO) has been shown to induce a drastic dephosphorylation of Serine 10 on histone H3.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Listeriolysin O(LLO) has been shown to decrease the level of associated phospho-Ser10 H3 of cxcl2 gene.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Listeriolysin O(LLO) has been shown to decrease the level of associated phospho-Ser10 H3 of Dusp4 gene.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Listeriolysin O(LLO) has been shown to increase the level of associated phospho-Ser10 H3 of Prkdc gene.
  Protein Name: Perfringolysin O
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Perfringolysin (PFO) has been shown to induce a drastic dephosphorylation of Serine 10 on histone H3.
  Protein Name: Pneumolysin
     Detailed Information Pro Info click to show the detail information of this protein [68]
     Description
Pneumolysin (PLY) has been shown to induce a drastic dephosphorylation of Serine 10 on histone H3.
  Protein Name: Aerolysin
     Detailed Information Pro Info click to show the detail information of this protein [69]
     Description
Aerolysin has been shown to dephosphorylates histone H3.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [69]
     Description
Listeriolysin O(LLO) has been shown to dephosphorylates histone H3.
  Protein Name: Adhesion and penetration protein
     Detailed Information Pro Info click to show the detail information of this protein [70]
     Description
Meningococcal serine protease A (MspA) has been shown to proteolytically cleave histone H3 in vitro.
  Protein Name: Meningococcal serine protease A
     Detailed Information Pro Info click to show the detail information of this protein [70]
     Description
Meningococcal serine protease A (MspA) has been shown to proteolytically cleave histone H3 in vitro.
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [71]
     Description
Rv2966c could bind to specific DNA sequences and interacted with the activating chromatin marks H3K4me3.
  Protein Name: Rv3763
     Detailed Information Pro Info click to show the detail information of this protein [72]
     Description
Rv3763 could inhibite the increased acetylation of histones H3 at CIITA pIV locus.

References
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2 Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Streptococcus pneumoniae Infection Promotes Histone H3 Dephosphorylation by Modulating Host PP1 Phosphatase. Cell Rep. 2020 Mar 24;30(12):4016-4026.e4. doi: 10.1016/j.celrep.2020.02.116.
5 Oxidative stress alters global histone modification and DNA methylation. Free Radic Biol Med. 2015 May;82:22-8. doi: 10.1016/j.freeradbiomed.2015.01.028. Epub 2015 Feb 3.
6 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
7 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
8 Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.
9 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
10 Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans Cell. 2016 May 5;165(4):842-53. doi: 10.1016/j.cell.2016.04.007. Epub 2016 Apr 28.
11 Biosynthesis of Vitamins by Probiotic Bacteria.
12 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.
13 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
14 The Gut Microbiota from Lean and Obese Subjects Contribute Differently to the Fermentation of Arabinogalactan and Inulin PLoS One. 2016 Jul 13;11(7):e0159236. doi: 10.1371/journal.pone.0159236. eCollection 2016.
15 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
16 Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation. FASEB J. 2019 Mar;33(3):3536-3548. doi: 10.1096/fj.201801848R. Epub 2018 Nov 19.
17 Methionine-dependent histone methylation at developmentally important gene loci in mouse preimplantation embryos. J Nutr Biochem. 2015 Dec;26(12):1664-9. doi: 10.1016/j.jnutbio.2015.08.009. Epub 2015 Aug 20.
18 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
19 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.
20 Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling. Int J Mol Med. 2015 Jun;35(6):1741-6. doi: 10.3892/ijmm.2015.2176. Epub 2015 Apr 8.
21 Hydrogen Sulfide and Sulfate Prebiotic Stimulates the Secretion of GLP-1 and Improves Glycemia in Male Mice Endocrinology. 2017 Oct 1;158(10):3416-3425. doi: 10.1210/en.2017-00391.
22 Vitamin K3 (menadione)-induced oncosis associated with keratin 8 phosphorylation and histone H3 arylation. Mol Pharmacol. 2005 Sep;68(3):606-15. doi: 10.1124/mol.105.013474. Epub 2005 Jun 6.
23 Effect of pH and dilution rate on specific production rate of extra cellular metabolites by Lactobacillus salivarius UCO_979C in continuous culture Appl Microbiol Biotechnol. 2015 Aug;99(15):6417-29. doi: 10.1007/s00253-015-6526-0. Epub 2015 Mar 25.
24 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
25 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
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