Details of Protein (Pro)

General Information of Protein (ID: PT023)
  Protein Name
Perfringolysin O
  Unify Protein name
Perfringolysin O
  Protein Synonym
Theta-toxin, Thiol-activated cytolysin
  Protein Entry
P0C2E9 
  Protein Entry name
TACY_CLOPE
  Protein Length
500AA
  Gene name
pfo
  Gene synonym
pfoA, pfoR
  Gene Location
Chromosome: 209,028-210,530

The epigenetic modification information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info HeLa cells serine 10 Clostridium perfringens infection [1]

The microbes that produce this protein
      Microbiota Name: Clostridium perfringens
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Clostridium perfringens is an anaerobic, gram-positive, spore-forming, rod-shaped pathogenic bacteria of the genus Clostridium.
      Microbiota Name: Streptococcus intermedius
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Streptococcus intermedius is an aerotolerant anaerobic commensal bacteria and a member of the Streptococcus anginosus group. Despite being commensal organisms, members of the S. anginosus group display wide pathogenic potential. S. intermedius has been isolated from patients with periodontitis and fatal purulent infections, especially brain and liver abscesses.

References
1 Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. doi: 10.1073/pnas.0702729104. Epub 2007 Aug 3.
2 The proteome of pus from human brain abscesses: host-derived neurotoxic proteins and the cell-type diversity of CNS pus J Neurosurg. 2018 Sep;129(3):829-837. doi: 10.3171/2017.4.JNS17284. Epub 2017 Oct 20.

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