Details of Protein (Pro) | MIAOME

General Information of Protein (ID: PT013)
Protein Name		RomA
Unify Protein name		Outer membrane protein RomA
Protein Entry		A0A378K3S0
Protein Entry name		A0A378K3S0_LEGPN
Protein Length		795AA
Gene name		NCTC12000_01356
Gene Location		SuperContig ERS1080593SCcontig000001: 1,389,474-1,391,861

The epigenetic modification information of this protein
Modification Type																				Molecule																				EM Info								Cell/Tissue Type																		Modified sites																						Condition															REF
Histone Acetylation																				H3																				EM Info								THP-1 cells																		lysine 14																						Legionella pneumophila infection															[1]
Histone Methylation																				H3																				EM Info								.																		lysine 14																						.															[2]
Histone Trimethylation																				H3K14																				EM Info								THP-1 cells																		CXCL1 promoter																						Legionella pneumophila infection															[1]
Histone Trimethylation																				H3K14																				EM Info								THP-1 cells																		CXCL2 promoter																						Legionella pneumophila infection															[1]

The microbes that produce this protein
Microbiota Name: Legionella pneumophila
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1]
Description		Legionella pneumophila is a thin, aerobic, pleomorphic, flagellated, non-spore-forming, gram-negative bacteria of the genus Legionella.
Microbiota Name: Legionella micdadei
Detailed Information		MIC Info click to show the detail information of this Microbiota					[2]
Description		Legionella micdadei is a gram-negative bacteria from the genus Legionella, which stains acid-fast. It stains weakly, but loses this trait upon being grown in culture.
Microbiota Name: Legionella fallonii
Detailed Information		MIC Info click to show the detail information of this Microbiota					[2]
Description		Legionella fallonii is a gram-negative, catalase-positive, weakly oxidase-positive bacteria from the genus Legionella which was isolated from a ship air-conditioning system
Microbiota Name: Legionella hackeliae
Detailed Information		MIC Info click to show the detail information of this Microbiota					[2]
Description		Legionella hackeliae is a gram-negative bacteria from the genus Legionella which was isolated from human lung aspirate in Pennsylvania.

References
1	Legionella pneumophila effector RomA uniquely modifies host chromatin to repress gene expression and promote intracellular bacterial replication Cell Host Microbe. 2013 Apr 17;13(4):395-405. doi: 10.1016/j.chom.2013.03.004.
2	Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones Cell Microbiol. 2015 Aug;17(8):1098-107. doi: 10.1111/cmi.12463.

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