Details of Protein (Pro)

General Information of Protein (ID: PT003)
  Protein Name
CagA
  Unify Protein name
Cytotoxicity-associated immunodominant antigen CagA 1
  Protein Entry
A0A1U9IUI1 
  Protein Entry name
A0A1U9IUI1_HELPX
  Protein Length
1,179AA
  Gene name
cagA_1
  Gene synonym
cagA_2, cagA_3, cagA_4
  Gene Location
Chromosome: 1,044,505-1,048,044

The epigenetic modification information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3B EM Info AGS cells . . [1]
DNA Methylation let-7 EM Info RGM1 cells promoter . [1]
Histone Methylation EZH2 EM Info AGS cells . . [1]
Histone Dephosphorylation H3 EM Info AGS cells serine 10 Helicobacter pylori infection [2]
Histone Trimethylation H3 EM Info RGM1 cells lysine 27 . [1]
miRNA let-7a EM Info AGS cells . . [1]
miRNA let-7c EM Info AGS cells . . [1]
miRNA miR-101 EM Info AGS cells . . [1]
miRNA miR-10a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-115 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-117 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-123 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-126 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-128 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-137 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-139 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-145 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-146 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-148 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-154 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-17 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-185 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-186 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-19 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-190 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-196 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-198 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-218 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-226a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-26a EM Info AGS cells . . [1]
miRNA miR-278 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-285 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-291-as EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-29c EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-30-as EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-301 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-304 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-305 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-306 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-307 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-308 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-309 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-310 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-320 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-337 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-338 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-343 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-34b EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-34c EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-351 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-36 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-371-3p EM Info AGS cells . Helicobacter pylori infection [4]
miRNA miR-372 EM Info AGS cells . Helicobacter pylori infection [4]
miRNA miR-373 EM Info AGS cells . Helicobacter pylori infection [4]
miRNA miR-39 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-40 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-409 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-411 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-44 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-46 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-52 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-57 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-6 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-61 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-62 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-64 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-68 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-69 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-73 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-86 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-87 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-90 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-99a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miRNA-1290 EM Info AGS cells . Helicobacter pylori infection [5]
miRNA miRNA-584 EM Info AGS cells . Helicobacter pylori infection [5]

The microbes that produce this protein
      Microbiota Name: Helicobacter pylori
         Detailed Information MIC Info click to show the detail information of this Microbiota [2]
         Description
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, helically-shaped, microaerophilic bacteria usually found in the stomach. Helicobacter pylori has been associated with the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye.
      Microbiota Name: Helicobacter pylori SS1
         Detailed Information MIC Info click to show the detail information of this Microbiota [4], [6]
         Description
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic, spiral bacteria usually found in the stomach. Its helical shape is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection.

References
1 CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis Gut. 2013 Nov;62(11):1536-46. doi: 10.1136/gutjnl-2011-301625. Epub 2012 Aug 30.
2 Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis PLoS One. 2010 Apr 1;5(4):e9875. doi: 10.1371/journal.pone.0009875.
3 Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1 Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G786-96. doi: 10.1152/ajpgi.00279.2013. Epub 2013 Oct 17.
4 Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Silence. 2011 Oct 25;2(1):7. doi: 10.1186/1758-907X-2-7.
5 MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells PLoS One. 2012;7(4):e35147. doi: 10.1371/journal.pone.0035147. Epub 2012 Apr 20.
6 Lactobacillus fermentum UCO-979C strongly inhibited Helicobacter pylori SS1 in Meriones unguiculatus Benef Microbes. 2018 Jun 15;9(4):625-627. doi: 10.3920/BM2017.0160. Epub 2018 Apr 10.

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