Details of Protein (Pro)

General Information of Protein (ID: PT002)
  Protein Name
HP0175
  Unify Protein name
Putative peptidyl-prolyl cis-trans isomerase HP_0175
  Protein Synonym
Rotamase HP_0175
  Protein Entry
P56112 
  Protein Entry name
Y175_HELPY
  Protein Length
299AA
  Gene name
HP_0175
  Gene Location
Chromosome: 181,865-182,764

The epigenetic modification information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation CASP8 EM Info Gall bladder cancer cells promoter . [1], [2]
DNA Methylation EGFR EM Info Gall bladder cancer cells promoter . [1], [2]
DNA Methylation HoxA2 EM Info Gall bladder cancer cells promoter . [1], [2]
DNA Methylation p53 EM Info Human multiple myeloma cells promoter . [1], [3]
DNA Methylation Survivin EM Info Gall bladder cancer cells promoter . [1], [2]
DNA Methylation Tastin EM Info Gall bladder cancer cells promoter . [1], [2]
DNA Methylation TFF1 EM Info Gall bladder cancer cells promoter . [1], [2]
Histone Phosphorylation H3S10 EM Info . IL-6 promoter . [1]
miRNA miR-29b-1-5p EM Info AGS cells . Helicobacter pylori infection [4]

The microbes that produce this protein
      Microbiota Name: Helicobacter pylori
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, helically-shaped, microaerophilic bacteria usually found in the stomach. Helicobacter pylori has been associated with the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye.

References
1 Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe. 2008 Aug 14;4(2):100-9. doi: 10.1016/j.chom.2008.07.009.
2 Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression Cancer Res. 2006 Nov 1;66(21):10517-24. doi: 10.1158/0008-5472.CAN-06-2130.
3 Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation Cancer Res. 2005 Jun 1;65(11):4673-82. doi: 10.1158/0008-5472.CAN-04-3589.
4 Genome-wide mRNA-miRNA profiling uncovers a role of the microRNA miR-29b-1-5p/PHLPP1 signalling pathway in Helicobacter pylori-driven matrix metalloproteinase production in gastric epithelial cells Cell Microbiol. 2018 Sep;20(9):e12859. doi: 10.1111/cmi.12859. Epub 2018 May 25.

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