Details of Metabolite (Meta)

General Information of Metabolite (ID: MT101)
  Meta Name
2-Aminoacetophenone
  Unify Name
2-Aminoacetophenone
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
2-Amino-1-phenyl-ethanone;2-Amino-1-phenylethan-1-one;2-Amino-1-phenylethanone;2-Amino-1-phenylethanone, 9ci;alpha-Aminoacetophenone;alpha-Aminoactophenone;alpha-Demethylcathinone;Benzoylmethylamine;Omega-aminoacetophenone;Phenacylamine;Phenomydrol;Ortho-aminoacetophenone;2-Aminoacetophenone hydrochloride;2-Aminoacetophenone;O-Aminoacetophenone
  Molecule Type
Aromatic compounds
  Formula
C8H9NO
  Inchi Key
HEQOJEGTZCTHCF-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): 2-Aminoacetophenone, also known as benzoylmethylamine or phenacylamine, belongs to the class of organic compounds known as alkyl-phenylketones. These are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. 2-Aminoacetophenone is a very strong basic compound (based on its pKa). Outside of the human body, 2-Aminoacetophenone has been detected, but not quantified in, cereals and cereal products and tortilla chips. This could make 2-aminoacetophenone a potential biomarker for the consumption of these foods.
  External Links   HMDB ID   HMDB0032628

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K18 EM Info Macrophages TNF-Alpha promoter Pseudomonas aeruginosa infection [1]
Histone Deacetylation HDAC1 EM Info THP-1 cells . Pseudomonas aeruginosa infection [2]

The microbes that produce this metabolite
      Pseudomonas aeruginosa
         Detailed Information MIC Info click to show the detail information of this Microbiota [2]
         Description
Pseudomonas aeruginosa is a gram-negative, rod-shaped, asporogenous, and monoflagellated bacteria that has an incredible nutritional versatility. It has been found in environments such as soil, water, humans, animals, plants, sewage and hospitals. It is known to cause chronic respiratory disease.

References
1 A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming. Nat Microbiol. 2016 Oct 3;1:16174. doi: 10.1038/nmicrobiol.2016.174.
2 [Advances in oral bacteria influencing host epigenetic regulation]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Oct 1;38(5):583-588. doi: 10.7518/hxkq.2020.05.019.

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