Details of Metabolite (Meta)

General Information of Metabolite (ID: MT049)
  Meta Name
Inositol phosphate
  Unify Name
Inositol phosphate
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
D-myo-Inositol (6)-monophosphate;D-myo-Inositol (6)-phosphate;I6P;Ins(6)P;Ins6p;D-myo-Inositol (6)-monophosphoric acid;Inositol phosphoric acid;D-myo-Inositol (6)-phosphoric acid;1D-myo-Inositol 1-monophosphate;1D-myo-Inositol 1-phosphate;D-myo-Inositol-1-phosphate;Inositol 1-monophosphate;
  Molecule Type
Other metabolites
  Formula
C6H11O9P
  Inchi Key
INAPMGSXUVUWAF-PTQMNWPWSA-L
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Inositol phosphate is an intermediate step in the metabolism of glucose-6-phosphate to myo-inositol. myo-Inositol is synthesized from glucose-6-phosphate (G-6-P) in two steps. First, G-6-P is isomerised by INYNA1 to myo-inositol 1-phosphate, which is then dephosphorylated by IMPA1 to give myo-inositol.
  External Links   HMDB ID   HMDB0002985
  VMH ID   mi1p_D
  KEGG ID   C01177
  Metlin ID   359

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K9 EM Info Intestinal epithelial cells Clec2e Iintestinal disease [1], [2]
Histone Acetylation H3K9 EM Info Intestinal epithelial cells Scd2 Iintestinal disease [1], [2]
Histone Deacetylation HDAC3 EM Info Intestinal epithelial cells . Iintestinal disease [3], [4]

The microbes that produce this metabolite
      Escherichia coli
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [4]
         Description
Escherichia coli, also known as E. coli, is a gram-negative, facultative anaerobic, rod-shaped, coliform bacteria of the genus Escherichia.

References
1 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
2 Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism Cell Host Microbe. 2020 Mar 11;27(3):358-375.e7. doi: 10.1016/j.chom.2020.01.028. Epub 2020 Feb 25.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Vitamin B(12) is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation. J Neuroinflammation. 2020 Apr 1;17(1):96. doi: 10.1186/s12974-020-01763-y.

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