Details of Protein (Pro) | MIAOME

General Information of Protein (ID: PT005)
Protein Name		Listeriolysin O
Unify Protein name		Listeriolysin O
Protein Synonym		LLO, Thiol-activated cytolysin
Protein Entry		P13128
Protein Entry name		TACY_LISMO
Protein Length		529AA
Gene name		hly
Gene synonym		hlyA, lisA
Gene ID		987033
Gene Location		Chromosome: 205,819-207,408

The epigenetic modification information of this protein
Modification Type																				Molecule																				EM Info								Cell/Tissue Type																		Modified sites																						Condition															REF
Histone Dephosphorylation																				H3																				EM Info								HeLa cells																		serine 10																						Listeria monocytogenes infection															[1]
Histone Dephosphorylation																				H3																				EM Info								HeLa cells																		.																						Listeriolysin O infection															[2]
Histone Phosphorylation																				H3S10																				EM Info								HeLa cells																		Cxcl2																						Listeria monocytogenes infection															[1]
Histone Phosphorylation																				H3S10																				EM Info								HeLa cells																		Dusp4																						Listeria monocytogenes infection															[1]
Histone Phosphorylation																				H3S10																				EM Info								HeLa cells																		Prkdc																						Listeria monocytogenes infection															[1]
Histone Deacetylation																				Histone H4																				EM Info								HeLa cells																		.																						Listeria monocytogenes infection															[1]
miRNA																				miR-146b																				EM Info								Epithelial cells																		.																						Listeriolysin O infection															[3]
miRNA																				miR-155																				EM Info								Epithelial cells																		.																						Listeriolysin O infection															[3]
miRNA																				miR-16																				EM Info								Epithelial cells																		.																						Listeriolysin O infection															[3]

The microbes that produce this protein
Microbiota Name: Listeria monocytogenes
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1]
Description		Listeria monocytogenes is the species of pathogenic bacteria that causes the infection listeriosis. It is a facultative anaerobic bacteria, capable of surviving in the presence or absence of oxygen.
Microbiota Name: Listeria
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1]
Description		Listeria infection is a foodborne bacterial illness that can be very serious for pregnant women, people older than 65 and people with weakened immune systems.
Microbiota Name: Listeria ivanovii
Detailed Information		MIC Info click to show the detail information of this Microbiota					[2]
Description		Listeria ivanovii is pathogenic primarily in animals, and the vast majority of both human and animal disease is caused by L. monocytogenes.

References
1	Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. doi: 10.1073/pnas.0702729104. Epub 2007 Aug 3.
2	K+ efflux is required for histone H3 dephosphorylation by Listeria monocytogenes listeriolysin O and other pore-forming toxins Infect Immun. 2011 Jul;79(7):2839-46. doi: 10.1128/IAI.01243-10. Epub 2011 Apr 11.
3	microRNA response to Listeria monocytogenes infection in epithelial cells Int J Mol Sci. 2012;13(1):1173-85. doi: 10.3390/ijms13011173. Epub 2012 Jan 20.

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