Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10073)
  Official Symbol
DNMT1
  Official Full Name
DNA methyltransferase 1
  Synonym
CXXC9;DNMT;MCMT
  Molecule Type
Protein coding
  Position On Chromosome
chr19(Start:10133345 - End:10231286)
  Strand
-
  Uniprot Entry
P26358 
  ENSG ID
ENSG00000130816 
  Dnmivd Disease
BRCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: 2-methylpropionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
2-methylpropionate has been shown to inhibite the DNA methyltransferase enzymes.
  Metabolite Name: Arachidonic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Arachidonic acid has been shown to inhibite the activity of DNA methyltransferase enzymes.
  Metabolite Name: Indole
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Indole has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Indole-3-acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Indole-3-acetate has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Cadaverine
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
Cadaverine has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Hexanoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [2]
     Description
Hexanoate has been shown to inhibite the DNA methyltransferase enzymes.
  Metabolite Name: Branched-chain fatty acids (BCFAs)
     Detailed Information Meta Info click to show the detail information of this Metabolite [2]
     Description
Branched SCFAs (BCFAs) has been shown to inhibite the DNA methyltransferase enzymes.
  Metabolite Name: Caproate
     Detailed Information Meta Info click to show the detail information of this Metabolite [2]
     Description
Caproate has been shown to inhibite the DNA methyltransferase enzymes.
  Metabolite Name: Phenolic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [7]
     Description
Phenolic acid has been shown to inhibit DNA Methyltransferases'(DNMT3B) activity by 60%-80%.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Benzoate has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Conjugated linoleic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Conjugated linoleic acid has been shown to inhibite the activity of DNA methyltransferase enzymes.
  Metabolite Name: Dimethylamine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Dimethylamine has been shown to activate DNA Methyltransferases.
  Metabolite Name: Dimethylglicine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Dimethylglicine has been shown to activate DNA Methyltransferases.
  Metabolite Name: Hydroxicinnamic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Hydroxicinnamic acid has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Hydroxybenzaldehyde
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Hydroxybenzaldehyde has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Hydroxyphenylacetic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Hydroxyphenylacetic acid has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Hydroxyphenylpentanoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Hydroxyphenylpentanoic acid has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Hydroxyphenylpropanoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Hydroxyphenylpropanoic acid has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Indole-3-aldehyde
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Indole-3-aldehyde has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Indole-3-carboxaldehyde
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Indole-3-carboxaldehyde has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Linoleic acid derivative
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Linoleic acid derivative has been shown to inhibite the activity of DNA methyltransferase enzymes.
  Metabolite Name: Methylamine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
Methylamine has been shown to activate DNA Methyltransferases.
  Metabolite Name: P-cresol
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [8]
     Description
P-cresol has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Valerolactone
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [9]
     Description
Valerolactone has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Pantothenic acid (B5)
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [10]
     Description
Pantothenic acid (B5) has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Quinolic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [11]
     Description
Quinolic acid has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Thiamine (B1)
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [12]
     Description
Thiamine (B1) has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Tryptamine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [13]
     Description
Tryptamine has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Spermine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [14]
     Description
Spermine has been shown to inhibit DNA Methyltransferases.
  Metabolite Name: Pyridoxine (B6)
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [15]
     Description
Pyridoxine (B6) has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Indole-3-propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [16], [17]
     Description
Indole-3-Propionate has been shown to activate the DNA methyltransferase enzymes.
  Metabolite Name: Thrimethylamine
     Detailed Information Meta Info click to show the detail information of this Metabolite [18], [2]
     Description
Thrimethylamine has been shown to activate DNA Methyltransferases.
  Metabolite Name: Vitamin K
     Detailed Information Meta Info click to show the detail information of this Metabolite [18], [2]
     Description
Vitamin K has been shown to activate the DNA methyltransferase enzymes.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
4 Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism Cell Host Microbe. 2020 Mar 11;27(3):358-375.e7. doi: 10.1016/j.chom.2020.01.028. Epub 2020 Feb 25.
5 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
6 Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.
7 Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils J Biomed Sci. 2012 Oct 12;19(1):89. doi: 10.1186/1423-0127-19-89.
8 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
9 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.
10 Vitamin B(12) is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation. J Neuroinflammation. 2020 Apr 1;17(1):96. doi: 10.1186/s12974-020-01763-y.
11 Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci. Sci Rep. 2019 Dec 24;9(1):19768. doi: 10.1038/s41598-019-56341-x.
12 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.
13 Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One. 2012;7(6):e39501. doi: 10.1371/journal.pone.0039501. Epub 2012 Jun 20.
14 Induction of autophagy by spermidine promotes longevity. Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4.
15 Biotinylation of histones represses transposable elements in human and mouse cells and cell lines and in Drosophila melanogaster. J Nutr. 2008 Dec;138(12):2316-22. doi: 10.3945/jn.108.098673.
16 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
17 Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii Microb Ecol. 2018 Jan;75(1):228-238. doi: 10.1007/s00248-017-1037-4. Epub 2017 Jul 18.
18 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.

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