Details of Metabolite (Meta)

General Information of Metabolite (ID: MT085)
  Meta Name
Cadaverine
  Unify Name
Cadaverine
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
1,5-Diaminopentane;1,5-Pentamethylenediamine;1,5-Pentanediamine;DAPE;Pentamethylenediamine;PENTANE-1,5-diamine;1,5-Diaminopentane dihydrochloride;Cadaverin;Cadaverine dihydrochloride;Pentamethylenediamine dihydrochloride;BioDex 1;1,5 Pentanediamine
  Molecule Type
Polyamines
  Formula
C5H16N2
  Inchi Key
VHRGRCVQAFMJIZ-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Cadaverine is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. However, this diamine is not purely associated with putrefaction. It is also produced in small quantities by mammals. In particular, it is partially responsible for the distinctive smell of urine and semen. Elevated levels of cadaverine have been found in the urine of some patients with defects in lysine metabolism. Cadaverine is toxic in large doses. In rats it had a low acute oral toxicity of more than 2000 mg/kg body weight (Wikipedia ). Cadaverine can be found in Corynebacterium (PMID: 27872963 ).
  External Links   HMDB ID   HMDB0002322
  VMH ID   15DAP
  KEGG ID   C01672
  Metlin ID   3236

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Demethylation Histone Demethylase (HDM) EM Info . . . [3], [2]

The microbes that produce this metabolite
      Clostridium saccharolyticum
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [2]
         Description
Lacrimispora saccharolytica is an anaerobic, mesophilic bacteria.
      Campilobacter jejuni
         Detailed Information MIC Info click to show the detail information of this Microbiota [4]
         Description
Campylobacter jejuni is a common cause of human gastroenteritis. It is a gram-negative, curved, slender, motile rod and is found in food, feces, and water.

References
1 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
2 Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.
3 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

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