Details of Metabolite (Meta)

General Information of Metabolite (ID: MT058)
  Meta Name
Hydroxyphenylacetic acid
  Unify Name
Ortho-Hydroxyphenylacetic acid
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
(O-Hydroxyphenyl)acetic acid;2'-Hydroxyphenylacetic acid;2-Hydroxybenzeneacetic acid;2-Hydroxyphenylacetic acid;O-Hydroxyphenylacetic acid;(O-Hydroxyphenyl)acetate;ortho-Hydroxyphenylacetate;2'-Hydroxyphenylacetate;2-Hydroxybenzeneacetate;2-Hydroxyphenylacetate;O-Hydroxyphenylacetate;(2-Hydroxyphenyl)acetate;(2-Hydroxyphenyl)acetic acid;(O-Hydroxyphenyl)-acetate;(O-Hydroxyphenyl)-acetic acid;2-HPAA;Hydroxyphenylacetate;Hydroxyphenylacetic acid;O-Hydroxyphenyl acetic acid;
  Molecule Type
Phenolic compounds
  Formula
C8H7O3
  Inchi Key
CCVYRRGZDBSHFU-UHFFFAOYSA-M
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Ortho-hydroxyphenylacetic acid, also known as (o-hydroxyphenyl)acetate or 2-hydroxybenzeneacetic acid, is a member of the class of compounds known as 2(hydroxyphenyl)acetic acids. 2(hydroxyphenyl)acetic acids are phenylacetic acids that carry a hydroxyl group at the 2-position. Ortho-hydroxyphenylacetic acid is slightly soluble (in water) and a weakly acidic compound (based on its pKa). Ortho-hydroxyphenylacetic acid can be found in a number of food items such as natal plum, lemon verbena, half-highbush blueberry, and parsley, which makes ortho-hydroxyphenylacetic acid a potential biomarker for the consumption of these food products. Ortho-hydroxyphenylacetic acid can be found primarily in blood, feces, and urine. Moreover, ortho-hydroxyphenylacetic acid is found to be associated with phenylketonuria, which is an inborn error of metabolism. ortho-Hydroxyphenylacetic acid is a substrate of the enzyme oxidoreductases (EC 1.14.13.-) in the pathway styrene degradation (KEGG).
  External Links   HMDB ID   HMDB0000669
  VMH ID   2hyoxplac
  KEGG ID   C05852
  Metlin ID   5639

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Deacetylation HDAC EM Info . . . [1], [2]

The microbes that produce this metabolite
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      Subdoligranulum
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Subdoligranulum is a genus of gram-negative, strictly anaerobic bacteria from the family Oscillospiraceae.
      Clostridium difficile
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Clostridioides difficile is a species of gram-positive, anaerobic bacteria from the genus Clostridioides.
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [4], [1]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.
4 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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