Details of Metabolite (Meta)

General Information of Metabolite (ID: MT010)
  Meta Name
Thrimethylamine
  Unify Name
Trimethylamine
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
(CH3)3N;N(CH3)3;N,N,N-Trimethylamine;N,N-Dimethylmethanamine;NMe3;TMA;Tridimethylaminomethane;Trimethylamin;Dimethylmethaneamine;N,N-Dimethyl-methanamine;N-Trimethylamine;Trimethylamine anhydrous;Trimethylamine aqueous solution;HI OF trimethylamine;HCL OF Trimethylamine;HBR OF Trimethylamine
  Molecule Type
Choline metabolites
  Formula
C3H9N
  Inchi Key
GETQZCLCWQTVFV-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Trimethylamine, also known as NMe3, N(CH3)3, and TMA, is a colorless, hygroscopic, and flammable simple amine with a typical fishy odor in low concentrations and an ammonia like odor in higher concentrations. Trimethylamine has a boiling point of 2.9 degree centigrade and is a gas at room temperature. Trimethylamine usually comes in pressurized gas cylinders or as a 40% solution in water. Trimethylamine is a nitrogenous base and its positively charged cation is called trimethylammonium cation. A common salt of trimethylamine is trimethylammonium chloride, a hygroscopic colorless solid.
  External Links   HMDB ID   HMDB0000906
  KEGG ID   C00565
  Metlin ID   3772

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Proteobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Proteobacteria is a major phylum of gram-negative bacteria. It includes a wide variety of pathogenic genera, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia, Legionellales, and many others.
      Actinobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Actinobacteria are ubiquitous gram-positive bacteria with high guanine and cytosine contents in DNA, having a characteristic filamentous morphology.
      Firmicutes
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [4]
         Description
Firmicutes is phylum of bacteria

References
1 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
4 Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs J Anim Sci Biotechnol. 2018 Jan 30;9:18. doi: 10.1186/s40104-018-0233-5. eCollection 2018.

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