Details of Metabolite (Meta) | MIAOME

General Information of Metabolite (ID: MT011)
Meta Name		Thiamine (B1)
Unify Name		Thiamine
Synonym		Click to Show/Hide the Detailed Synonyms of This Metabolite 3-(4-AMINO-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium;Aneurin;Antiberiberi factor;Thiamin;Thiamine(1+) ion;Thiaminium;Vitamin b1;Apate drops;Beatine;Bedome;Begiolan;Benerva;Bequin;Berin;Betalin S;Betaxin;Bethiazine;Beuion;Bevitex;Bevitine;Bewon;Biamine;Bithiamin;Biuno;Bivatin;Bivita;Cernevit-12;Clotiamina;Eskapen;Eskaphen;Hybee;Lixa-beta;Metabolin;Slowten;THD;Thiadoxine;Thiaminal;Thiamol;Thiavit;Tiamidon;Tiaminal;Trophite;Vetalin S;VIB;Vinothiam;Vitaneuron;Mononitrate, thiamine;Thiamine mononitrate;Vitamin b 1
Molecule Type		Vitamins
Formula		C12H17N4OS
Inchi Key		JZRWCGZRTZMZEH-UHFFFAOYSA-N
Description		Click to Show/Hide the Detailed Description of This Metabolite belongs to the class of organic compounds known as thiamines. Thiamines are compounds containing a thiamine moiety, which is structurally characterized by a 3-[(4-Amino-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-thiazol-5-yl backbone.
External Links		HMDB ID		HMDB0000235
		VMH ID		THM
		KEGG ID		C00378

The epigenetic modification information of this metabolite
Modification Type																				Molecule																				EM Info								Cell/Tissue Type																		Modified sites																						Condition														REF
DNA Methylation																				DNMT																				EM Info								.																		.																						.														[1], [2]
Histone Methylation																				HMT																				EM Info								.																		.																						.														[1], [2]
Histone Deacetylation																				Sirtuin 4																				EM Info								.																		.																						.														[1], [2]

The microbes that produce this metabolite
Bacillus subtilis
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1], [2]
Description		Bacillus subtilis, known also as the hay bacillus or grass bacillus, is a gram-positive, catalase-positive bacteria, found in soil and the gastrointestinal tract of ruminants and humans.
Fusobacteria
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1], [2]
Description		Fusobacteria are obligately anaerobic non-sporeforming gram-negative bacilli.
Proteobacteria
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1], [2]
Description		Proteobacteria is a major phylum of gram-negative bacteria. It includes a wide variety of pathogenic genera, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia, Legionellales, and many others.
Actinobacteria
Detailed Information		MIC Info click to show the detail information of this Microbiota					[1], [2]
Description		Actinobacteria are ubiquitous gram-positive bacteria with high guanine and cytosine contents in DNA, having a characteristic filamentous morphology.

References
1	Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2	Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.

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