Details of Metabolite (Meta)

General Information of Metabolite (ID: MT073)
  Meta Name
Dimethylglicine
  Unify Name
Dimethylglycine
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
(Dimethylamino)acetic acid;2-(Dimethylamino)acetic acid;N,N-Dimethylaminoacetic acid;N-Methylsarcosine;(Dimethylamino)acetate;2-(Dimethylamino)acetate;N,N-Dimethylaminoacetate;N,N-Dimethylglycine;N-Methylsarcosine N,N-dimethyl-glycine;Dimethylglycine, monopotassium salt;Dimethylglycine, sodium salt;Dimethylglycine, calcium salt;Dimethylglycine monohydrochloride;2-(N,N-Dimethylamino)acetic acid;DMG;Dimethylglycine
  Molecule Type
Choline metabolites
  Formula
C4H9NO2
  Inchi Key
FFDGPVCHZBVARC-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Dimethylglycine (DMG) is an amino acid derivative found in the cells of all plants and animals and can be obtained in the diet in small amounts from grains and meat. The human body produces DMG when metabolizing choline into glycine. Dimethylglycine that is not metabolized in the liver is transported by the circulatory system to body tissue. Dimethylglycine was popular with Russian athletes and cosmonauts owing to its reputed ability to increase endurance and reduce fatigue. DMG is also a byproduct of homocysteine metabolism. Homocysteine and betaine are converted to methionine and N,N-dimethylglycine by betaine-homocysteine methyltransferase. DMG in the urine is a biomarker for the consumption of legumes. It is also a microbial metabolite (PMID: 25901889 ).
  External Links   HMDB ID   HMDB0000092
  VMH ID   DMGLY
  KEGG ID   C01026
  Metlin ID   277

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      proteobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Proteobacteria is a major phylum of gram-negative bacteria. It includes a wide variety of pathogenic genera, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia, Legionellales, and many others.
      Actinobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Actinobacteria are ubiquitous gram-positive bacteria with high guanine and cytosine contents in DNA, having a characteristic filamentous morphology.
      Firmicutes
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Firmicutes is phylum of bacteria

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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