Details of Metabolite (Meta)

General Information of Metabolite (ID: MT004)
  Meta Name
Vitamin K
  Unify Name
Vitamin-K
  Molecule Type
Vitamins
  Formula
C11H7O2R
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Vitamin K refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements. The human body requires vitamin K for post-synthesis modification of certain proteins that are required for blood coagulation or for controlling binding of calcium in bones and other tissues.
  External Links
  VMH ID   M03145
  KEGG ID   C01628

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Acetylation Histone Acetylase (HAT) EM Info . . . [2], [3]
Histone Methylation HMT EM Info . . . [2], [3]
Histone Deacetylation Sirtuin 4 EM Info . . . [2], [4]

The microbes that produce this metabolite
      Bacillus subtilis
         Detailed Information MIC Info click to show the detail information of this Microbiota [2], [3]
         Description
Bacillus subtilis, known also as the hay bacillus or grass bacillus, is a gram-positive, catalase-positive bacteria, found in soil and the gastrointestinal tract of ruminants and humans.
      Fusobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [2], [3]
         Description
Fusobacteria are obligately anaerobic non-sporeforming gram-negative bacilli.
      Proteobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [2], [3]
         Description
Proteobacteria is a major phylum of gram-negative bacteria. It includes a wide variety of pathogenic genera, such as Escherichia, Salmonella, Vibrio, Helicobacter, Yersinia, Legionellales, and many others.
      Actinobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [2], [3]
         Description
Actinobacteria are ubiquitous gram-positive bacteria with high guanine and cytosine contents in DNA, having a characteristic filamentous morphology.
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [2], [4]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
3 High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74. doi: 10.1186/s13148-017-0374-y. eCollection 2017.
4 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.

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