Details of Metabolite (Meta)

General Information of Metabolite (ID: MT100)
  Meta Name
2-methylpropionate
  Unify Name
Isobutyric acid
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
2,2-Dimethylacetic acid;2-METHYL-propionIC ACID;2-Methylpropanoate;2-Methylpropanoic acid;2-Methylpropionsaeure;alpha-Isobutyric acid;alpha-Methylpropanoic acid;alpha-Methylpropionic acid;Dimethylacetic acid;iso-Butyric acid;iso-C3H7COOH;Isobutanoate;Isobutanoic acid;Isobuttersaeure;Isobutyrate;Isopropylformic acid;2,2-Dimethylacetate;2-METHYL-propionate;a-Isobutyrate;a-Isobutyric acid;alpha-Isobutyrate;Alpha-isobutyrate;Alpha-isobutyric acid;a-Methylpropanoate;a-Methylpropanoic acid;alpha-Methylpropanoate;Alpha-methylpropanoate;Alpha-methylpropanoic acid;a-Methylpropionate;a-Methylpropionic acid;alpha-Methylpropionate;Alpha-methylpropionate;Alpha-methylpropionic acid;Dimethylacetate;iso-Butyrate;Isopropylformate;2-Methylpropionate;2-Methylpropionic acid;I-butyrate;I-butyric acid;Ammonium isobutyrate;Isobutyric acid, ammonium salt;Isobutyric acid, sodium salt;2-Methpropanoic acid;Isobutyric acid, hemiammoniate;Sodium isobutyrate;Isobutyric acid, calcium salt;Isobutyric acid, nickel salt;Isobutyric acid, potassium salt;Isobutyric acid, sodium salt, 11C-labeled;Isobutyric acid, sodium salt, 14C-labeled;
  Molecule Type
Short-chain fatty acids (SCFAs)
  Formula
C4H7O2
  Inchi Key
KQNPFQTWMSNSAP-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Isobutyric acid is a carboxylic or short chain fatty acid with characteristic sweat-like smell. Small amount of isobutyrate is generated via microbial (gut) metabolism. Small amounts may also be found in certain foods or fermented beverages. There is anosmia (genetic inability to smell) for the odor of isobutyric acid with a frequency of about 2.5%. (OMIM 207000). Isobutyric acid is slightly soluble in water but much more soluble in ethanol, ether and organic solvents. Isobutyric acid can affect people if breathed in and may be absorbed through the skin. Contact can irritate and burn the skin and eyes. Breathing Isobutyric acid can irritate the nose, throat and lungs causing coughing, wheezing and/or shortness of breath.
  External Links   HMDB ID   HMDB0001873
  VMH ID   isobut
  KEGG ID   C02632
  Metlin ID   106

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.