General Information of Metabolite (ID: MT061)
  Meta Name
Hydroxicinnamic acid
  Unify Name
Hydrocinnamic acid
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
3-Phenyl-propionic acid;3-Phenylpropanoic acid;3-Phenylpropionsaeure;3PP;Benzenepropanoic acid;Benzenepropionic acid;Benzylacetic acid;beta-Phenylpropionic acid;Dihydrocinnamic acid;Hydrozimtsaeure;Phenylpropanoate;3-Phenylpropionic acid;3-Phenyl-propionate;3-Phenylpropanoate;Benzenepropanoate;Benzenepropionate;Benzylacetate;b-Phenylpropionate;b-Phenylpropionic acid;beta-Phenylpropionate;beta-phenylpropionate;beta-phenylpropionic acid;Dihydrocinnamate;Phenylpropanoic acid;3-Phenylpropionate;Hydrocinnamate;3-Phenyl-N-propionate;3-Phenyl-N-propionic acid;Omega-phenylpropanoate;Omega-phenylpropanoic acid;W-Phenylpropanoate;W-Phenylpropanoic acid;3-Phenylpropionic acid, sodium salt;3-Phenyl propionic acid;HYDROCINNAMIC ACID;Phenylpropionic acid;beta-Phenylpropanoic acid;beta-Phenylpropanoic acid;omega-Phenylpropanoic acid
  Molecule Type
Phenolic compounds
  Formula
C9H10O2
  Inchi Key
XMIIGOLPHOKFCH-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Hydrocinnamic acid, also known as phenylpropanoate or dihydrocinnamate, belongs to the class of organic compounds known as phenylpropanoic acids. Phenylpropanoic acids are compounds with a structure containing a benzene ring conjugated to a propanoic acid. Hydrocinnamic acid is a drug. Hydrocinnamic acid is a weakly acidic compound (based on its pKa). Hydrocinnamic acid exists in all living organisms, ranging from bacteria to humans. Phenylpropanoic acid can be prepared from cinnamic acid by hydrogenation. Hydrocinnamic acid is a sweet, balsamic, and cinnamon tasting compound. Outside of the human body, hydrocinnamic acid has been detected, but not quantified in, several different foods, such as macadamia nuts, watercress, bamboo shoots, lupines, and ohelo berries. This could make hydrocinnamic acid a potential biomarker for the consumption of these foods. This compound is used frequently in cosmetic products such as perfumes, bath gels, detergent powders, liquid detergents, fabric softeners, and soaps as it gives off a floral scent. A characteristic reaction of phenylpropanoic acid is its cyclization to indanones. Phenylpropanoic acid is used in the food industry to preserve and maintain the original aroma quality of frozen foods. Phenylpropanoic acid is also added to food for technological purposes in a wide variety including manufacturing, processing, preparation, treatment, packaging, transportation or storage, and food additives. This compound is used as a sweetener as well to sweeten food and can be found in table top sweeteners. It is a white, crystalline solid with a sweet, floral scent at room temperature.
  External Links   HMDB ID   HMDB0000764
  KEGG ID   C05629
  Metlin ID   4153

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Acetylation Histone Acetylase (HAT) EM Info . . . [3], [4]
Histone Methylation HMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      Subdoligranulum
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Subdoligranulum is a genus of gram-negative, strictly anaerobic bacteria from the family Oscillospiraceae.
      Clostridium difficile
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [4]
         Description
Clostridioides difficile is a species of gram-positive, anaerobic bacteria from the genus Clostridioides.
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [5], [1]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
4 Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria PLoS Pathog. 2018 Sep 12;14(9):e1007191. doi: 10.1371/journal.ppat.1007191. eCollection 2018 Sep.
5 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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