Details of Metabolite (Meta)

General Information of Metabolite (ID: MT056)
  Meta Name
Hydroxyphenylpropanoic acid
  Unify Name
Desaminotyrosine
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
3-(4-Hydroxyphenyl)propionic acid;3-(p-Hydroxyphenyl)propionic acid;4-Hydroxyphenylpropionic acid;beta-(p-Hydroxyphenyl)propionic acid;Dihydro-p-coumaric acid;HYDROXYPHENYL propionIC ACID;p-Hydroxyhydrocinnamic acid;p-Hydroxyphenylpropionic acid;Phloretinic acid;Phloretic acid;3-(4-Hydroxyphenyl)propionate;3-(p-Hydroxyphenyl)propionate;4-Hydroxyphenylpropionate;b-(p-Hydroxyphenyl)propionate;b-(p-Hydroxyphenyl)propionic acid;beta-(p-Hydroxyphenyl)propionate;beta-(p-hydroxyphenyl)propionate;beta-(p-hydroxyphenyl)propionic acid;Dihydro-p-coumarate;HYDROXYPHENYL propionate;p-Hydroxyhydrocinnamate;p-Hydroxyphenylpropionate;Phloretinate;Phloretate;3-(4'-Hydroxyphenyl)-propionate;3-(4'-Hydroxyphenyl)-propionic acid;3-(4'-Hydroxyphenyl)propionic acid;3-(4-Hydroxy-phenyl)-propionate;3-(4-Hydroxy-phenyl)-propionic acid;3-(4-Hydroxyphenyl)-propionate;3-(4-Hydroxyphenyl)-propionic acid;3-(4-Hydroxyphenyl)propanoate;3-(4-Hydroxyphenyl)propanoic acid;3-(Para-hydroxyphenyl)propionate;3-(Para-hydroxyphenyl)propionic acid;4'-Hydroxyphenylpropionic acid;4-(4-Hydroxyphenylpropanoate;4-(4-Hydroxyphenylpropanoic acid;4-Hydroxy-(9ci)benzenepropanoate;4-Hydroxy-(9ci)benzenepropanoic acid;4-Hydroxy-benzenepropanoate;4-Hydroxy-benzenepropanoic acid;4-Hydroxybenzenepropanoate;4-Hydroxybenzenepropanoic acid;Hydro-p-coumarate;Hydro-p-coumaric acid;Hydroxy-hydrocinnamic acid;N-Hydroxysuccinimide ester;p-Hydroxy-benzene propionate;p-Hydroxy-benzene propionic acid;p-Hydroxy-hydrocinnamate;p-Hydroxy-hydrocinnamic acid;4-Hydroxyhydrocinnamic acid;Desaminotyrosine
  Molecule Type
Phenolic compounds
  Formula
C9H9O3
  Inchi Key
NMHMNPHRMNGLLB-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Desaminotyrosine is a normal constituent of human urine. A product of tyrosine metabolism; concentration in urine increases in patients with gastrointestinal diseases. (Dictionary of Organic Compounds). It is considered also that may result from metabolism to phenolic acids by colonic bacteria. (PMID 15315398).
  External Links   HMDB ID   HMDB0002199
  VMH ID   phppa
  KEGG ID   C01744
  Metlin ID   4148

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Deacetylation HDAC EM Info . . . [1], [2]
Histone Acetylation Histone Acetylase (HAT) EM Info . . . [1], [2]
Histone Methylation HMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      Subdoligranulum
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Subdoligranulum is a genus of gram-negative, strictly anaerobic bacteria from the family Oscillospiraceae.
      Clostridium difficile
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Clostridioides difficile is a species of gram-positive, anaerobic bacteria from the genus Clostridioides.
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [4], [1]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.
4 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

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