Details of Metabolite (Meta)

General Information of Metabolite (ID: MT033)
  Meta Name
Pantothenic acid (B5)
  Unify Name
Pantothenic acid
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
(+)-Pantothenic acid;(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine;Chick antidermatitis factor;D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine;D-(+)-Pantothenic acid;D-Pantothenic acid;N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-beta-alanine;PANTOTHENOIC ACID;Vitamin b5;Pantothen pharmaselect;(R)-Pantothenate;(+)-Pantothenate;(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine;(R)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine;D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine;D(+)-N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine;D-(+)-Pantothenate;D-Pantothenate;N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-b-alanine;N-[(2R)-2,4-Dihydroxy-3,3-dimethylbutanoyl]-beta-alanine;PANTOTHENOate;(R)-Pantothenic acid;Pantothenate;b5, Vitamin;Pantothenate, zinc;b 5, Vitamin;Calcium pantothenate;Pantothenate, calcium;Vitamin b 5;Dexol;Zinc pantothenate;Pantothenic acid
  Molecule Type
Vitamins
  Formula
C9H16NO5
  Inchi Key
GHOKWGTUZJEAQD-UHFFFAOYSA-M
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Pantothenic acid, also called vitamin B5, is a water-soluble vitamin required to sustain life. Pantothenic acid is needed to form coenzyme-A (CoA), and is thus critical in the metabolism and synthesis of carbohydrates, proteins, and fats. Its name is derived from the Greek pantothen meaning "from everywhere" and small quantities of pantothenic acid are found in nearly every food, with high amounts in whole grain cereals, legumes, eggs, meat, and royal jelly.
  External Links   HMDB ID   HMDB0000210
  VMH ID   pnto_R
  KEGG ID   C00864
  Metlin ID   241

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
Histone Methylation HMT EM Info . . . [3], [1]
Histone Deacetylation Sirtuin 4 EM Info . . . [3], [1]

The microbes that produce this metabolite
      Bacillus subtilis
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [1]
         Description
Bacillus subtilis, known also as the hay bacillus or grass bacillus, is a gram-positive, catalase-positive bacteria, found in soil and the gastrointestinal tract of ruminants and humans.
      Fusobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [1]
         Description
Fusobacteria are obligately anaerobic non-sporeforming gram-negative bacilli.
      Actinobacteria
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [1]
         Description
Actinobacteria are ubiquitous gram-positive bacteria with high guanine and cytosine contents in DNA, having a characteristic filamentous morphology.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Vitamin B(12) is neuroprotective in experimental pneumococcal meningitis through modulation of hippocampal DNA methylation. J Neuroinflammation. 2020 Apr 1;17(1):96. doi: 10.1186/s12974-020-01763-y.
3 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.

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