Details of Metabolite (Meta)

General Information of Metabolite (ID: MT051)
  Meta Name
Indole-3-carboxaldehyde
  Unify Name
Inosine
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
9-beta-D-Ribofuranosyl-9H-purin-6-ol;9-beta-D-Ribofuranosylhypoxanthine;Hypoxanthine D-riboside;Hypoxanthosine;i;Inosin;Inosina;Inosinum;9-b-D-Ribofuranosyl-9H-purin-6-ol;9-beta-D-ribofuranosyl-9H-purin-6-ol;9-b-D-Ribofuranosylhypoxanthine;9-beta-D-ribofuranosylhypoxanthine;(-)-Inosine;1,9-dihydro-9-b-D-Ribofuranosyl-6H-purin-6-one;1,9-dihydro-9-beta-D-Ribofuranosyl-6H-purin-6-one;1,9-dihydro-9-beta-delta-Ribofuranosyl-6H-purin-6-one;9-b-D-Ribofuranosyl-hypoxanthine;9-beta-D-Ribofuranosyl-hypoxanthine;9-beta-delta-Ribofuranosyl-hypoxanthine;9-beta-delta-Ribofuranosylhypoxanthine;9beta-D-Ribofuranosylhypoxanthine;9beta-delta-Ribofuranosylhypoxanthine;Atorel;beta-D-Ribofuranoside hypoxanthine-9;beta-delta-Ribofuranoside hypoxanthine-9;beta-Inosine;HXR;Hypoxanthine 9-beta-D-ribofuranoside;Hypoxanthine 9-beta-delta-ribofuranoside;Hypoxanthine nucleoside;Hypoxanthine ribonucleoside;Hypoxanthine riboside;Hypoxanthine-9 beta-D-ribofuranoside;Hypoxanthine-9 beta-delta-ribofuranoside;Hypoxanthine-9-beta-D-ribofuranoside;Hypoxanthine-9-beta-delta-ribofuranoside;Hypoxanthine-9-D-ribofuranoside;Hypoxanthine-9-delta-ribofuranoside;Hypoxanthine-ribose;Indole-3-carboxaldehyde;Ino;Inosie;iso-Prinosine;Oxiamin;Panholic-L;Pantholic-L;Ribonosine;Selfer;Trophicardyl
  Molecule Type
Tryptophan metabolites
  Formula
C10H12N4O5
  Inchi Key
UGQMRVRMYYASKQ-KQYNXXCUSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules (Dorland, 28th ed). Inosine is found to be associated with purine nucleoside phosphorylase deficiency and xanthinuria type I, which are inborn errors of metabolism.
  External Links   HMDB ID   HMDB0000195
  VMH ID   ins
  KEGG ID   C00294
  Metlin ID   84

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]

The microbes that produce this metabolite
      Escherichia coli
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [4]
         Description
Escherichia coli, also known as E. coli, is a gram-negative, facultative anaerobic, rod-shaped, coliform bacteria of the genus Escherichia.
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      Eubacterium hallii
         Detailed Information MIC Info click to show the detail information of this Microbiota [5]
         Description
Anaerobutyricum hallii is an anaerobic bacteria that lives inside the human digestive system.
      Clostridium sporogenes
         Detailed Information MIC Info click to show the detail information of this Microbiota [1]
         Description
Clostridium sporogenes is a species of gram-positive bacteria that belongs to the genus Clostridium.
      Lactobacillus spp.
         Detailed Information MIC Info click to show the detail information of this Microbiota [3], [6]
         Description
Lactobacillus sp. is a bacteria of gram-positive, aerotolerant anaerobics or microaerophilic, rod-shaped, non-spore-forming bacteria.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
4 Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism Cell Host Microbe. 2020 Mar 11;27(3):358-375.e7. doi: 10.1016/j.chom.2020.01.028. Epub 2020 Feb 25.
5 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
6 Antifungal Activity of Lactobacillus pentosusOCK 0979 in the Presence of Polyols and Galactosyl-Polyols Probiotics Antimicrob Proteins. 2018 Jun;10(2):186-200. doi: 10.1007/s12602-017-9344-0.

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