Details of Microbe Species (MIC)

General Information of MIC (ID: MC0722)
  MIC Name
Subdoligranulum
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Oscillospiraceae
Genus: Subdoligranulum
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Negative
  Description
Subdoligranulum is a genus of gram-negative, strictly anaerobic bacteria from the family Oscillospiraceae.
  External Links Taxonomy ID 292632
GutMDisorder ID gm0628

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Phenolic compounds
           Metabolite Name: Benzoate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Benzoylation H3K4 EM Info HepG2 cells TKbzQTAR (modified peptide) . [1]
Histone Benzoylation H4K8 EM Info HepG2 cells GKacGGKbzGLGKacGGAKacR (modified peptide) . [1]
Histone Benzoylation H2BK5 EM Info HepG2 cells PEPTKbzSAPAPK (modified peptide) . [1]
Histone Benzoylation H3K14 EM Info HepG2 cells STGGKbzAPR (modified peptide) . [1]
Histone Benzoylation H3K18 EM Info HepG2 cells KbzQLATKacAAR (modified peptide) . [1]
Histone Benzoylation H3K23 EM Info HepG2 cells KQLATKbzAAR (modified peptide) . [1]
Histone Benzoylation H3K9 EM Info HepG2 cells KbzSTGGKacAPR (modified peptide) . [1]
Histone Benzoylation H4K12 EM Info HepG2 cells GLGKbzGGAKacR (modified peptide) . [1]
Histone Benzoylation H4K16 EM Info HepG2 cells GGKprGLGKprGGAKbzR (modified peptide) . [1]
Histone Benzoylation H4K5 EM Info HepG2 cells GKbzGGKacGLGKacGGAKacR (modified peptide) . [1]
Histone Benzoylation H2BK11 EM Info HepG2 cells SAPAPKbzK (modified peptide) . [1]
Histone Benzoylation H2BK16 EM Info HepG2 cells KbzAVTKacAQK(modified peptide) . [1]
Histone Benzoylation H2BK20 EM Info HepG2 cells KAVTKbzAQK(modified peptide) . [1]
Histone Benzoylation H2AK13 EM Info HepG2 cells AKbzAKprSR (modified peptide) . [1]
Histone Benzoylation H2AK9 EM Info HepG2 cells GKacQGGKbzAR (modified peptide) . [1]
           Metabolite Name: Hydroxicinnamic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1]
Histone Acetylation Histone Acetylase (HAT) EM Info . . . [1]
Histone Methylation HMT EM Info . . . [1]
           Metabolite Name: Hydroxybenzaldehyde Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1]
           Metabolite Name: Hydroxycoumarin Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC1 EM Info Epithelial cells Nrf2 promoter . [1], [2]
           Metabolite Name: Hydroxyphenylacetic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [3]
Histone Deacetylation HDAC EM Info . . . [1], [3]
           Metabolite Name: Hydroxyphenylpentanoic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [3]
Histone Deacetylation HDAC EM Info . . . [1], [3]
Histone Methylation HMT EM Info . . . [1], [3]
           Metabolite Name: Hydroxyphenylpropanoic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [3]
Histone Acetylation Histone Acetylase (HAT) EM Info . . . [1], [3]
Histone Deacetylation HDAC EM Info . . . [1], [3]
Histone Methylation HMT EM Info . . . [1], [3]
           Metabolite Name: P-cresol Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [3]
Histone Deacetylation HDAC EM Info . . . [1], [3]
Histone Methylation HMT EM Info . . . [1], [3]
           Metabolite Name: Valerolactone Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [3]
Histone Deacetylation HDAC EM Info . . . [1], [3]
Histone Methylation HMT EM Info . . . [1], [3]


References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 7-Hydroxycoumarin Attenuates Colistin-Induced Kidney Injury in Mice Through the Decreased Level of Histone Deacetylase 1 and the Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2020 Jul 28;11:1146. doi: 10.3389/fphar.2020.01146. eCollection 2020.
3 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.

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