Details of Metabolite (Meta)

General Information of Metabolite (ID: MT059)
  Meta Name
Hydroxycoumarin
  Unify Name
3 Hydroxycoumarin
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
3-Hydroxy-2-benzopyrone;3-Hydroxy-2H-1-benzopyran-2-one;3-Hydroxy-coumarin;3-Hydroxycoumarin;O-Hydroxyphenylpyruvic acid lacton
  Molecule Type
Phenolic compounds
  Formula
C9H6O3
  Inchi Key
MJKVTPMWOKAVMS-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
3 Hydroxycoumarin belongs to the class of organic compounds known as hydroxycoumarins. These are coumarins that contain one or more hydroxyl groups attached to the coumarin skeleton. 3 Hydroxycoumarin is an extremely weak basic (essentially neutral) compound (based on its pKa).
  External Links   HMDB ID   HMDB0002149
  Metlin ID   6512

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC1 EM Info Epithelial cells Nrf2 promoter . [1], [2]

The microbes that produce this metabolite
      Bifidobacterium
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Bifidobacteria is a genus of gram-positive, nonmotile, often branched anaerobic bacteria. They are ubiquitous inhabitants of the gastrointestinal tract, vagina and mouth of mammals, including humans.
      Subdoligranulum
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [3]
         Description
Subdoligranulum is a genus of gram-negative, strictly anaerobic bacteria from the family Oscillospiraceae.
      Clostridium difficile
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [4]
         Description
Clostridioides difficile is a species of gram-positive, anaerobic bacteria from the genus Clostridioides.
      Lactobacillus
         Detailed Information MIC Info click to show the detail information of this Microbiota [5], [1]
         Description
Lactobacillus is a genus of gram-positive, facultative anaerobic or microaerophilic, rod-shaped, non-spore-forming bacteria. They are a major part of the lactic acid bacteria group. In humans, they constitute a significant component of the microbiota at a number of body sites, such as the digestive system, urinary system, and genital system.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 7-Hydroxycoumarin Attenuates Colistin-Induced Kidney Injury in Mice Through the Decreased Level of Histone Deacetylase 1 and the Activation of Nrf2 Signaling Pathway. Front Pharmacol. 2020 Jul 28;11:1146. doi: 10.3389/fphar.2020.01146. eCollection 2020.
4 Lysine benzoylation is a histone mark regulated by SIRT2. Nat Commun. 2018 Aug 28;9(1):3374. doi: 10.1038/s41467-018-05567-w.
5 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.