Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10070)
  Official Symbol
HNMT
  Official Full Name
histamine N-methyltransferase
  Synonym
HMT;MRT51;HNMT-S1;HNMT-S2
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:137964020 - End:138016364)
  Strand
+
  Uniprot Entry
P50135 
  ENSG ID
ENSG00000150540 
  Dnmivd Disease
CHOL 
Metabolite(s) with this epigenetic modification
  Metabolite Name: S-Adenosyl Homocysteine (SAH)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
S-Adenosyl homocysteine (SAH) is a product inhibitor of methyltransferases.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Benzoate has been shown to inhibit histone methyltransferase.
  Metabolite Name: Hydroxicinnamic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Hydroxicinnamic acid has been shown to inhibit histone methyltransferase.
  Metabolite Name: Hydroxyphenylpentanoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Hydroxyphenylpentanoic acid has been shown to inhibit histone methyltransferase.
  Metabolite Name: Hydroxyphenylpropanoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Hydroxyphenylpropanoic acid has been shown to inhibit histone methyltransferase.
  Metabolite Name: P-cresol
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
P-cresol has been shown to inhibit histone methyltransferase.
  Metabolite Name: Pyridoxine (B6)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [5]
     Description
Pyridoxine (B6) has been shown to activate histone methyltransferase.
  Metabolite Name: Vitamin K
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [6]
     Description
Vitamin K has been shown to activate histone methyltransferase.
  Metabolite Name: Thiamine (B1)
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [7]
     Description
Thiamine (B1) has been shown to activate histone methyltransferase.
  Metabolite Name: Valerolactone
     Detailed Information Meta Info click to show the detail information of this Metabolite [8], [9]
     Description
Valerolactone has been shown to inhibit histone methyltransferase.
  Metabolite Name: Pantothenic acid (B5)
     Detailed Information Meta Info click to show the detail information of this Metabolite [10], [3]
     Description
Pantothenic acid (B5) has been shown to activate histone methyltransferase.

References
1 Epigenetics: A New Bridge between Nutrition and Health. Adv Nutr. 2010 Nov;1(1):8-16. doi: 10.3945/an.110.1004. Epub 2010 Nov 16.
2 Lactobacillus paracasei metabolism of rice bran reveals metabolome associated with Salmonella Typhimurium growth reduction. J Appl Microbiol. 2017 Jun;122(6):1639-1656. doi: 10.1111/jam.13459. Epub 2017 May 11.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
5 Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. J Nutr Biochem. 2008 Jun;19(6):400-8. doi: 10.1016/j.jnutbio.2007.06.002. Epub 2007 Sep 27.
6 High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74. doi: 10.1186/s13148-017-0374-y. eCollection 2017.
7 Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3. Hum Mol Genet. 2013 Jul 1;22(13):2662-75. doi: 10.1093/hmg/ddt115. Epub 2013 Mar 7.
8 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
9 Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria PLoS Pathog. 2018 Sep 12;14(9):e1007191. doi: 10.1371/journal.ppat.1007191. eCollection 2018 Sep.
10 Response of MiRNA-22-3p and MiRNA-149-5p to Folate Deficiency and the Differential Regulation of MTHFR Expression in Normal and Cancerous Human Hepatocytes. PLoS One. 2017 Jan 3;12(1):e0168049. doi: 10.1371/journal.pone.0168049. eCollection 2017.

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