Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10044)
  Official Symbol
HIST2H2AC
  Official Full Name
histone cluster 2, H2ac
  Synonym
H2A;H2A-GL101;H2A/q;H2AFQ
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:149858525 - End:149858961)
  Strand
+
  Uniprot Entry
Q16777 
  ENSG ID
ENSG00000184260 
  Dnmivd Disease
READ 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-5 promoter.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-6 promoter.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-7 promoter.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-8 promoter.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-3 promoter.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Benzoate has been shown to enhance the H2AK13 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Benzoate has been shown to enhance the H2AK9 benzoylation levels in HepG2 cells.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H2A at K12
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H2A at K125
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H2A at K127
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H2A at K13
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H2A at K9
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-4 promoter.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at AGRP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at ARNT2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at ASCL1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at AVP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at BMP7 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at CARTPT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at CCK loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at CORT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at CRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at GALP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at GAST loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at GHRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at GNRH2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at HCRT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at HMX2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at KISS1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at LHX1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at NKX2-1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at NPVF loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at NPW loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at NPY loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at NR5A1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at OTP loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at OXT loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at PDYN loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at PENK loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at PNOC loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at POMC loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at POU3F2 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at PRLH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at RAX loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at SHH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at SIM1 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at SIX3 loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at SST loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at TRH loci.
  Metabolite Name: Kynurenine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Kynurenine has been shown to increase H2AS40Gc at VAX1 loci.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-2 promoter.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [1]
     Description
Biotin (B7) is associated with the biotinylation on histone H2A at K9 at IL-9 promoter.

Protein(s) with this epigenetic modification
  Protein Name: TRP120
     Detailed Information Pro Info click to show the detail information of this protein [7]
     Description
TRP120 recruits PCGF isoforms from the nucleus to the ehrlichial vacuole

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs J Anim Sci Biotechnol. 2018 Jan 30;9:18. doi: 10.1186/s40104-018-0233-5. eCollection 2018.
3 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
4 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
5 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
6 Valerian and valeric acid inhibit growth of breast cancer cells possibly by mediating epigenetic modifications. Sci Rep. 2021 Jan 28;11(1):2519. doi: 10.1038/s41598-021-81620-x.
7 Ehrlichia chaffeensis TRP120 Effector Targets and Recruits Host Polycomb Group Proteins for Degradation To Promote Intracellular Infection. Infect Immun. 2018 Mar 22;86(4):e00845-17. doi: 10.1128/IAI.00845-17. Print 2018 Apr.

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