Details of Microbe Species (MIC)

General Information of MIC (ID: MC1038)
  MIC Name
Helicobacter pylori
  Synonym
Campylobacter pylori subsp. pylori
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
  Oxygen Sensitivity
Microaerophile
  Microbial Metabolism
Respiratory
  Gram
Negative
  Host Relationship
Opportunistic pathogen
  Genome Size (bp)
1667867
  No. of Coding Genes
1576
  No. of Non-Coding Genes
41
  No. of Small Non-Coding Genes
41
  No. of Gene Transcripts
1617
  No. of Base Pairs
1617653
  Description
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, helically-shaped, microaerophilic bacteria usually found in the stomach. Helicobacter pylori has been associated with the mucosa-associated lymphoid tissue in the stomach, esophagus, colon, rectum, or tissues around the eye.
  External Links Taxonomy ID 210
GutMDisorder ID gm0367
Genome Assembly ID BCM-300
GOLD Database ID Go0455605
GIMICA ID MIC00669

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Other metabolites
           Metabolite Name: Nitric oxide (NO) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation RUNX3 EM Info Epithelial cells . Helicobacter pylori infection [1]

Full List of Protein(s) Produced by This MIC
     Protein Type: .
           Protein Name: CagA Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info AGS cells serine 10 Helicobacter pylori infection [2]
miRNA miR-10a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-128 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-145 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-146 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-320 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-34c EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-291-as EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-17 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-278 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-87 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-198 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-301 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-351 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-19 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-218 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-115 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-411 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-29c EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-117 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-185 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-305 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-69 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-61 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-40 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-126 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-196 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-139 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-310 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-62 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-46 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-307 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-186 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-90 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-148 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-64 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-36 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-409 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-44 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-338 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-309 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-34b EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-137 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-73 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-57 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-68 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-154 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-52 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-337 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-190 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-123 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-99a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-285 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-6 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-30-as EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-226a EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-86 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-343 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-306 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-304 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-39 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
miRNA miR-308 EM Info Gastric epithelial cells . Helicobacter pylori infection [3]
           Protein Name: cagPAI Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info AGS cells serine 10 Helicobacter pylori infection [2]
Histone Dephosphorylation H3 EM Info MKN45 cells serine 10 Helicobacter pylori infection [2]
           Protein Name: vacA Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Dephosphorylation H3 EM Info AGS cells serine 10 Helicobacter pylori infection [2]
     Protein Type: Microbial secreted proteins
DNA Methylation DNMT3B EM Info AGS cells . . [4]
DNA Methylation let-7 EM Info RGM1 cells promoter . [4]
Histone Trimethylation H3 EM Info RGM1 cells lysine 27 . [4]
Histone Methylation EZH2 EM Info AGS cells . . [4]
miRNA miRNA-584 EM Info AGS cells . Helicobacter pylori infection [5]
miRNA miRNA-1290 EM Info AGS cells . Helicobacter pylori infection [5]
miRNA miR-373 EM Info AGS cells . Helicobacter pylori infection [6]
miRNA miR-372 EM Info AGS cells . Helicobacter pylori infection [6]
miRNA miR-371-3p EM Info AGS cells . Helicobacter pylori infection [6]
miRNA let-7a EM Info AGS cells . . [4]
miRNA let-7c EM Info AGS cells . . [4]
miRNA miR-101 EM Info AGS cells . . [4]
miRNA miR-26a EM Info AGS cells . . [4]
Histone Acetylation H3 EM Info . lysine 23 . [7]
           Protein Name: HP0175 Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation p53 EM Info Human multiple myeloma cells promoter . [8], [9]
DNA Methylation TFF1 EM Info Gall bladder cancer cells promoter . [8], [10]
DNA Methylation Tastin EM Info Gall bladder cancer cells promoter . [8], [10]
DNA Methylation Survivin EM Info Gall bladder cancer cells promoter . [8], [10]
DNA Methylation HoxA2 EM Info Gall bladder cancer cells promoter . [8], [10]
DNA Methylation EGFR EM Info Gall bladder cancer cells promoter . [8], [10]
DNA Methylation CASP8 EM Info Gall bladder cancer cells promoter . [8], [10]
Histone Phosphorylation H3S10 EM Info . IL-6 promoter . [8]
miRNA miR-29b-1-5p EM Info AGS cells . Helicobacter pylori infection [11]

References
1 Epigenetic modifications induced by Helicobacter pylori infection through a direct microbe-gastric epithelial cells cross-talk. Med Microbiol Immunol. 2013 Oct;202(5):327-37. doi: 10.1007/s00430-013-0301-6. Epub 2013 May 29.
2 Helicobacter pylori-induced histone modification, associated gene expression in gastric epithelial cells, and its implication in pathogenesis PLoS One. 2010 Apr 1;5(4):e9875. doi: 10.1371/journal.pone.0009875.
3 Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1 Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G786-96. doi: 10.1152/ajpgi.00279.2013. Epub 2013 Oct 17.
4 CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis Gut. 2013 Nov;62(11):1536-46. doi: 10.1136/gutjnl-2011-301625. Epub 2012 Aug 30.
5 MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells PLoS One. 2012;7(4):e35147. doi: 10.1371/journal.pone.0035147. Epub 2012 Apr 20.
6 Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Silence. 2011 Oct 25;2(1):7. doi: 10.1186/1758-907X-2-7.
7 Bacterial remodelling of the host epigenome: functional role and evolution of effectors methylating host histones Cell Microbiol. 2015 Aug;17(8):1098-107. doi: 10.1111/cmi.12463.
8 Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe. 2008 Aug 14;4(2):100-9. doi: 10.1016/j.chom.2008.07.009.
9 Interleukin 6 supports the maintenance of p53 tumor suppressor gene promoter methylation Cancer Res. 2005 Jun 1;65(11):4673-82. doi: 10.1158/0008-5472.CAN-04-3589.
10 Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression Cancer Res. 2006 Nov 1;66(21):10517-24. doi: 10.1158/0008-5472.CAN-06-2130.
11 Genome-wide mRNA-miRNA profiling uncovers a role of the microRNA miR-29b-1-5p/PHLPP1 signalling pathway in Helicobacter pylori-driven matrix metalloproteinase production in gastric epithelial cells Cell Microbiol. 2018 Sep;20(9):e12859. doi: 10.1111/cmi.12859. Epub 2018 May 25.

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