Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00056)
  Official Symbol
HOXA2
  Official Full Name
homeobox A2
  Synonym
HOX1K
  Molecule Type
Protein coding
  Position On Chromosome
chr7(Start:27100354 - End:27102686)
  Strand
-
  Uniprot Entry
O43364 
  ENSG ID
ENSG00000105996 
  Dnmivd Disease
COAD 
Protein(s) with this epigenetic modification
  Protein Name: HP0175
     Detailed Information Pro Info click to show the detail information of this protein [1], [2]
     Description
HP0175 responsible for IL-6 expression could be increase the HoxA2 gene promoter methylation.
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [3]
     Description
Rv2966c could hypomethylate the non-CpG dinucleotides at the host HOXA2 (TSS) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe. 2008 Aug 14;4(2):100-9. doi: 10.1016/j.chom.2008.07.009.
2 Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression Cancer Res. 2006 Nov 1;66(21):10517-24. doi: 10.1158/0008-5472.CAN-06-2130.
3 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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