Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10626)
  Official Symbol
MIRLET7C
  Official Full Name
microRNA let-7c
  Synonym
MIRNLET7C;hsa-let-7c
  Molecule Type
miRNA
  Position On Chromosome
chr21(Start:16539828 - End:16539911)
  Strand
+
  ENSG ID
ENSG00000199030 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Lipopolysaccharide (LPS) has been shown to downregulate let-7c (p < 0.05) in heLa cells.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Lipopolysaccharide (LPS) has been shown to downregulate let-7c (p < 0.05) in macrophages.

Protein(s) with this epigenetic modification
  Protein Name: CagA
     Detailed Information Pro Info click to show the detail information of this protein [2]
     Description
The cytotoxin-associated gene A (CagA) of Helicobacter pylori mediates epigenetic regulation to attenuate let-7c expression.

References
1 Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family EMBO J. 2011 May 18;30(10):1977-89. doi: 10.1038/emboj.2011.94. Epub 2011 Apr 5.
2 CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis Gut. 2013 Nov;62(11):1536-46. doi: 10.1136/gutjnl-2011-301625. Epub 2012 Aug 30.

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