Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM12534)
Metabolite(s) with this epigenetic modification
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Lipopolysaccharide (LPS) has been shown to downregulate miR-891a in human macrophages.

Protein(s) with this epigenetic modification
  Protein Name: CagA
     Detailed Information Pro Info click to show the detail information of this protein [2]
     Description
Helicobacter pylori upregulates miR-291-as (20.98 fold) in a cagA-dependent manner in vitro.

References
1 MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun. 2014 Jul;20(5):540-51. doi: 10.1177/1753425913501914. Epub 2013 Sep 23.
2 Strain-specific suppression of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the antiapoptotic protein Mcl-1 Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G786-96. doi: 10.1152/ajpgi.00279.2013. Epub 2013 Oct 17.

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