Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM04488)
  Official Symbol
EZH2
  Official Full Name
enhancer of zeste 2 polycomb repressive complex 2 subunit
  Synonym
ENX-1;ENX1;EZH1;EZH2b;KMT6;KMT6A;WVS;WVS2
  Molecule Type
Protein coding
  Position On Chromosome
chr7(Start:148504475 - End:148581413)
  Strand
-
  Uniprot Entry
Q15910 
  ENSG ID
ENSG00000106462 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A00: Primary neoplasms of brain Oligodendroglial tumors [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2A90: Mature T-cell lymphoma, specified types, nodal or systemic Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic]
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         2B50: Chondrosarcoma Central chondrosarcoma [Chondrosarcoma]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B72: Malignant neoplasms of stomach Gastric primary tumor [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C10: Malignant neoplasm of pancreas Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas]
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         2C12: Malignant neoplasms of liver or intrahepatic bile ducts Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C31: Squamous cell carcinoma of skin Cutaneous squamous cell carcinoma [Squamous cell carcinoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C73: Malignant neoplasms of ovary Ovarian carcinoma (OVCA) [Malignant neoplasms of ovary]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         2E66: Carcinoma in situ of cervix uteri Cervical intraepithelial neoplasia [Carcinoma in situ of cervix uteri]
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         4A20: Acquired immunodeficiencies Immunodeficiency [Acquired immunodeficiencies]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         4A43: Overlap or undifferentiated nonorgan specific systemic autoimmune disease Sjgren's Syndrome [Overlap or undifferentiated nonorgan specific systemic autoimmune disease]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         5A61: Hypofunction or certain specified disorders of pituitary gland Congenital hypopituitarism [Hypofunction or certain specified disorders of pituitary gland]
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         5B81: Obesity Obesity [Obesity]
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         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6B01: Panic disorder Panic Disorder [Panic disorder]
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         6C40: Disorders due to use of alcohol Alcohol use disorder (AUD) [Disorders due to use of alcohol]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
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         8E49: Postviral fatigue syndrome Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) [Postviral fatigue syndrome]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CA23: Asthma Asthma [Asthma]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         FA0Z: Osteoarthritis Osteoarthritis (OA) [Osteoarthritis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         LA02: Spina bifida Myelomeningocele [Spina bifida]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LA4Z: Clefts of lip, alveolus or palate Non-syndromic cleft lip and palate [Clefts of lip, alveolus or palate]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
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         LD44: Deletions of the autosomes Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XB1Y: Familial Familial recurrent moles (RHM) [Familial]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1ND9: Papillary carcinoma of thyroid Papillary thyroid carcinoma [Papillary carcinoma of thyroid]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH46F1: Clear cell renal cell carcinoma Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4V32: Ductal carcinoma in situ Ductal carcinoma in situ (DCIS) [Ductal carcinoma in situ]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
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         XH68V1: Liver cell adenoma Hepatocellular adenoma [Liver cell adenoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH74S1: Adenocarcinoma Small bowel adenocarcinoma [Adenocarcinoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8844: Oligodendroglioma, anaplastic Anaplastic oligodendrogliomas/oligoastrocytomas [Oligodendroglioma, anaplastic]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8D74: Carcinomatosis Cancer [Carcinomatosis]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH8SH6: CNS embryonal tumour Primitive neuroectodermal tumors [CNS embryonal tumour]
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         XH94U0: Pituitary adenoma Nonfunctioning pituitary adenomas [Pituitary adenoma]
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         XH98Z3: Schwannoma Schwannoma [Schwannoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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         ZERO(Not Found): Acute mania and inflammatory Acute mania and inflammatory [Acute mania and inflammatory]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Butyrate has been shown to downregulate expression of enhancer of zeste homolog2 (EZH2)
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Acetate has been shown to downregulate expression of enhancer of zeste homolog2 (EZH2)
  Metabolite Name: Iso-butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3]
     Description
Iso-butyrate has been shown to downregulate expression of enhancer of zeste homolog2 (EZH2)
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Propionate has been shown to downregulate expression of enhancer of zeste homolog2 (EZH2)
  Metabolite Name: Iso-Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [6]
     Description
Iso-valerate has been shown to downregulate expression of enhancer of zeste homolog2 (EZH2)

Protein(s) with this epigenetic modification
  Protein Name: CagA
     Detailed Information Pro Info click to show the detail information of this protein [7]
     Description
The cytotoxin-associated gene A (CagA) of Helicobacter pylori clearly acted to increase EZH2 expression, which is a histone methyltransferase in RGM1 cells.
  Protein Name: Rv2966c
     Detailed Information Pro Info click to show the detail information of this protein [8]
     Description
Rv2966c could hypermethylate the non-CpG dinucleotides at the host EZH2 (intergenic) genetic loci during Mycobacterium tuberculosis H37Rv infection.

References
1 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
2 Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes. Clin Oral Investig. 2013 May;17(4):1279-85. doi: 10.1007/s00784-012-0816-z. Epub 2012 Aug 9.
3 Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol. 2014 Apr;88(8):4466-79. doi: 10.1128/JVI.03326-13. Epub 2014 Feb 5.
4 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
5 Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria Cell Mol Life Sci. 2012 Aug;69(15):2583-92. doi: 10.1007/s00018-012-0936-2. Epub 2012 Feb 10.
6 MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun. 2014 Jul;20(5):540-51. doi: 10.1177/1753425913501914. Epub 2013 Sep 23.
7 CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis Gut. 2013 Nov;62(11):1536-46. doi: 10.1136/gutjnl-2011-301625. Epub 2012 Aug 30.
8 Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection. Sci Rep. 2016 Apr 26;6:25006. doi: 10.1038/srep25006.

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