Details of Microbe Species (MIC)

General Information of MIC (ID: MC0745)
  MIC Name
Eubacterium hallii
  Synonym
Eubacterium hallii
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Anaerobutyricum
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Description
Anaerobutyricum hallii is an anaerobic bacteria that lives inside the human digestive system.
  External Links Taxonomy ID 39488
GutMDisorder ID gm0314

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Demethylation DPPA2 EM Info iPS cells promoter . [1]
DNA Demethylation POU5F1 EM Info iPS cells promoter . [1]
Histone Acetylation H3 EM Info CD41T cells Foxo3A promoter . [1]
Histone Crotonylation H3K9 EM Info KGN cells GPR43 . [1]
Histone Deacetylation HDAC2 EM Info . . . [1]
Histone Deacetylation HDAC1 EM Info . . . [1]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [1]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info intestinal epithelial cells . . [3], [4]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [5]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [3], [4]
     Molecule Type: Tryptophan metabolites
           Metabolite Name: Indole Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [5], [6]
           Metabolite Name: Indole-3-acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [5], [4]
           Metabolite Name: Indole-3-aldehyde Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [5], [4]
           Metabolite Name: Indole-3-carboxaldehyde Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [7]
           Metabolite Name: Indole-3-Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [8], [4]
           Metabolite Name: Kynurenine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells AGRP . [9], [4]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells ARNT2 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells ASCL1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells AVP . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells BMP7 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CARTPT . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CCK . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CORT . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CRH . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GALP . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GAST . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GHRH . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GNRH2 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells HCRT . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells HMX2 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells KISS1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells LHX1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NKX2-1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPVF . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPW . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPY . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NR5A1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells OTP . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells OXT . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PDYN . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PENK . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PNOC . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells POMC . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells POU3F2 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PRLH . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells RAX . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SHH . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SIM1 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SIX3 . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SST . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells TRH . [1], [2]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells VAX1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells AGRP . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells ARNT2 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells ASCL1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells AVP . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells BMP7 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CARTPT . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CCK . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CORT . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CRH . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GALP . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GAST . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GHRH . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GNRH2 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells HCRT . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells HMX2 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells KISS1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells LHX1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NKX2-1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPVF . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPW . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPY . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NR5A1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells OTP . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells OXT . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PDYN . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PENK . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PNOC . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells POMC . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells POU3F2 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PRLH . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells RAX . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SHH . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SIM1 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SIX3 . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SST . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells TRH . [1], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells VAX1 . [1], [2]
           Metabolite Name: Quinolic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [10], [4]
           Metabolite Name: Serotonin Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation SLC6A4 EM Info T cells promoter Health [7]
           Metabolite Name: Tryptamine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [11]


References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci. Sci Rep. 2019 Dec 24;9(1):19768. doi: 10.1038/s41598-019-56341-x.
3 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
4 Mucin Cross-Feeding of Infant Bifidobacteria and Eubacterium hallii Microb Ecol. 2018 Jan;75(1):228-238. doi: 10.1007/s00248-017-1037-4. Epub 2017 Jul 18.
5 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
6 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
7 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
8 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
9 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
10 Butyrate drives the acetylation of histone H3K9 to activate steroidogenesis through PPAR-gamma and PGC1-alpha pathways in ovarian granulosa cells. FASEB J. 2021 Feb;35(2):e21316. doi: 10.1096/fj.202000444R.
11 Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One. 2012;7(6):e39501. doi: 10.1371/journal.pone.0039501. Epub 2012 Jun 20.

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