Details of Microbe Species (MIC)

General Information of MIC (ID: MC1113)
  MIC Name
Porphyromonas gingivalis
  Synonym
Bacteroides gingivalis
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Porphyromonadaceae
Genus: Porphyromonas
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Fermentative
  Gram
Negative
  Host Relationship
Pathogen
  Description
Porphyromonas gingivalis belongs to the phylum Bacteroidetes and is a nonmotile, gram-negative, rod-shaped, anaerobic, pathogenic bacteria. It forms black colonies on blood agar.
  External Links Taxonomy ID 837
GIMICA ID MIC01000

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [1]
Histone Methylation EZH2 EM Info BCBL1 cells . Periodontitis [1]
Histone Methylation SUV39H1 EM Info BCBL1 cells . Periodontitis [1]
           Metabolite Name: Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation EZH2 EM Info BCBL1 cells . Periodontitis [2]
Histone Methylation SUV39H1 EM Info BCBL1 cells . Periodontitis [2]
miRNA miR-92a EM Info Colon cancer cells . Colon cancer [3]
           Metabolite Name: Iso-Butyrate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation EZH2 EM Info BCBL1 cells . Periodontitis [3]
Histone Methylation SUV39H1 EM Info BCBL1 cells . Periodontitis [3]
           Metabolite Name: Iso-Valerate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info Erythroid cells . Abnormalities in BCAA metabolism [4]
Histone Methylation EZH2 EM Info BCBL1 cells . Periodontitis [4]
Histone Methylation SUV39H1 EM Info BCBL1 cells . Periodontitis [4]
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation SUV39H1 EM Info BCBL1 cells . Periodontitis [5], [6]
Histone Methylation EZH2 EM Info BCBL1 cells . Periodontitis [7], [6]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [6], [8]
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [6], [9]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info HaCaT cells . . [10], [11]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [6]
DNA Methylation DNMT1 EM Info HaCaT cells . . [4]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [6]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [6]
Histone Acetylation Histone acetyltransferase p300 EM Info Oral epithelial cells . Periodontitis [6]
Histone Deacetylation HDAC2 EM Info hPDLSCs . Periodontitis [6]
Histone Deacetylation HDAC1 EM Info hPDLSCs . Periodontitis [6]
Histone Demethylation JMJD3 EM Info HaCaT cells . . [10], [11]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [6], [9]
miRNA let-7f EM Info THP-1 cells . Cigarette smoke [6]
miRNA miR-29b EM Info THP-1 cells . Cigarette smoke [6]
miRNA miR-32 EM Info THP-1 cells . Cigarette smoke [6]
miRNA miR-891a EM Info THP-1 cells . Cigarette smoke [6]


References
1 Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes. Clin Oral Investig. 2013 May;17(4):1279-85. doi: 10.1007/s00784-012-0816-z. Epub 2012 Aug 9.
2 Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation. Eur J Histochem. 2017 Aug 25;61(3):2826. doi: 10.4081/ejh.2017.2826.
3 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
4 MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun. 2014 Jul;20(5):540-51. doi: 10.1177/1753425913501914. Epub 2013 Sep 23.
5 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
6 Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol. 2014 Apr;88(8):4466-79. doi: 10.1128/JVI.03326-13. Epub 2014 Feb 5.
7 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
8 Intermediaries of branched chain amino acid metabolism induce fetal hemoglobin, and repress SOX6 and BCL11A, in definitive erythroid cells. Blood Cells Mol Dis. 2015 Aug;55(2):161-7. doi: 10.1016/j.bcmd.2015.05.006. Epub 2015 May 27.
9 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
10 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
11 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

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