Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10068)
  Official Symbol
Histone
  Official Full Name
Histone
Metabolite(s) with this epigenetic modification
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Butyrate has been shown to exert anti-inflammatory effects in the colon by stimulating histone acetylation of the Foxp3 (forkhead box P3) locus in naive CD4+ T cells
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Lipopolysaccharide (LPS) has been shown to induce histone acetylation (lysine 9).
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Lipopolysaccharide (LPS) has been shown to induce histone phosphorylation (serine 10).

Protein(s) with this epigenetic modification
  Protein Name: Acetyltransferase
     Detailed Information Pro Info click to show the detail information of this protein [5]
     Description
Salmonella enterica acetyltransferase has been shown to acetylate histone proteins.

References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Effect of Lactobacillus acidophilus D2/CSL (CECT 4529) supplementation in drinking water on chicken crop and caeca microbiome PLoS One. 2020 Jan 24;15(1):e0228338. doi: 10.1371/journal.pone.0228338. eCollection 2020.
3 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
4 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
5 Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe. 2008 Aug 14;4(2):100-9. doi: 10.1016/j.chom.2008.07.009.

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