Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10064)
  Official Symbol
SUV39H1
  Official Full Name
suppressor of variegation 3-9 homolog 1
  Synonym
H3-K9-HMTase 1;KMT1A;MG44;SUV39H
  Molecule Type
Protein coding
  Position On Chromosome
chrx(Start:48553945 - End:48567403)
  Strand
+
  Uniprot Entry
O43463 
  ENSG ID
ENSG00000101945 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Choline
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Choline deficiencycould hypermethylate the Suv39h1 in liver.
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3]
     Description
Butyrate has been shown to downregulate suppressor of variegation 3-9 homolog1 (SUV39H1)
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Acetate has been shown to downregulate suppressor of variegation 3-9 homolog1 (SUV39H1)
  Metabolite Name: Iso-butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [5]
     Description
Iso-butyrate has been shown to downregulate suppressor of variegation 3-9 homolog1 (SUV39H1)
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [7]
     Description
Propionate has been shown to downregulate suppressor of variegation 3-9 homolog1 (SUV39H1)
  Metabolite Name: Iso-Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [8]
     Description
Iso-valerate has been shown to downregulate suppressor of variegation 3-9 homolog1 (SUV39H1)

References
1 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
2 Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem. 2009 Jan 23;284(4):1982-9. doi: 10.1074/jbc.M807651200. Epub 2008 Nov 10.
3 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
4 Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes. Clin Oral Investig. 2013 May;17(4):1279-85. doi: 10.1007/s00784-012-0816-z. Epub 2012 Aug 9.
5 Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol. 2014 Apr;88(8):4466-79. doi: 10.1128/JVI.03326-13. Epub 2014 Feb 5.
6 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
7 Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria Cell Mol Life Sci. 2012 Aug;69(15):2583-92. doi: 10.1007/s00018-012-0936-2. Epub 2012 Feb 10.
8 MicroRNAs responsive to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis LPS modulate expression of genes regulating innate immunity in human macrophages. Innate Immun. 2014 Jul;20(5):540-51. doi: 10.1177/1753425913501914. Epub 2013 Sep 23.

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