Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10422)
  Official Symbol
DNMT3A
  Official Full Name
DNA methyltransferase 3 alpha
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:25227855 - End:25342590)
  Strand
-
  Uniprot Entry
Q9Y6K1 
  ENSG ID
ENSG00000119772 
  Dnmivd Disease
BLCA 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Lipopolysaccharide (LPS) could downregulate DNMT3A (p < 0.05) gene expression in HaCaT cells.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Lipopolysaccharide could be associated with the downregulation of the DNMT3A gene.

References
1 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
2 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
3 Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production. Nutrients. 2019 Feb 19;11(2):433. doi: 10.3390/nu11020433.
4 Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics. 2013 Feb;5(1):51-63. doi: 10.2217/epi.12.74.

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