Details of Microbe Species (MIC)

General Information of MIC (ID: MC0943)
  MIC Name
Bacteroides thetaiotaomicron
  Synonym
Bacillus thetaiotaomicron, Bacteroides fragilis subsp. thetaiotaomicron, Pseudobacterium thetaiotaomicron, Sphaerocillus thetaiotaomicron
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Pathogen
  No. of Coding Genes
5071
  No. of Non-Coding Genes
88
  No. of Small Non-Coding Genes
88
  No. of Gene Transcripts
5159
  Description
Bacteroides thetaiotaomicron is a species of bacteria of the genus Bacteroides. It is a gram-negative obligate anaerobic. It is one of the most common bacteria found in human gut microbiota and is also an opportunistic pathogen.
  External Links Taxonomy ID 818
Genome Assembly ID ASM131497v1
GIMICA ID MIC00179

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [3]
DNA Methylation DNMT3B EM Info . . . [1], [3]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [3], [4]
Histone Acetylation H3 EM Info . . . [1], [3]
Histone Acetylation H4 EM Info . . . [1], [3]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [3], [5]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [3], [4]
Histone Deacetylation HDAC6 EM Info . . . [1], [3]
Histone Deacetylation HDAC7 EM Info . . . [1], [3]
     Molecule Type: Phenolic compounds
           Metabolite Name: Phenolic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [6], [7]
     Molecule Type: Polyamines
           Metabolite Name: Spermine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3B EM Info Jurkat cells . . [1], [8]
DNA Methylation DNMT3A EM Info Jurkat cells . . [1], [8]
Histone Acetylation H3 EM Info HT1080 cells . . [1], [9]
Histone Acetylation HAT1 EM Info HT1080 cells . . [1], [9]
Histone Deacetylation HDAC1 EM Info HT1080 cells . . [1], [9]
Histone Deacetylation SIRT1 EM Info HT1080 cells . . [1], [9]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
3 Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans Cell. 2016 May 5;165(4):842-53. doi: 10.1016/j.cell.2016.04.007. Epub 2016 Apr 28.
4 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
5 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
6 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
7 Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils J Biomed Sci. 2012 Oct 12;19(1):89. doi: 10.1186/1423-0127-19-89.
8 Extracellular Spermine Activates DNA Methyltransferase 3A and 3B. Int J Mol Sci. 2019 Mar 12;20(5):1254. doi: 10.3390/ijms20051254.
9 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.

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