Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00027)
  Official Symbol
HDAC6
  Official Full Name
histone deacetylase 6
  Synonym
FLJ16239;HD6;JM21;KIAA0901;PPP1R90
  Molecule Type
Protein coding
  Position On Chromosome
chrX(Start:48801377 - End:48824982)
  Strand
+
  Uniprot Entry
Q9UBN7 
  ENSG ID
ENSG00000094631 
  Dnmivd Disease
PRAD 
    Disease Relevance (Click to Show/Hide)
         1B10: Tuberculosis of the respiratory system Tuberculosis (TB) [Tuberculosis of the respiratory system]
            Detailed Information Disease Link click to show the detail information of this Disease
         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
            Detailed Information Disease Link click to show the detail information of this Disease
         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
            Detailed Information Disease Link click to show the detail information of this Disease
         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C12: Malignant neoplasms of liver or intrahepatic bile ducts Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
            Detailed Information Disease Link click to show the detail information of this Disease
         2C73: Malignant neoplasms of ovary Ovarian carcinoma (OVCA) [Malignant neoplasms of ovary]
            Detailed Information Disease Link click to show the detail information of this Disease
         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
            Detailed Information Disease Link click to show the detail information of this Disease
         5B81: Obesity Obesity [Obesity]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         6A20: Schizophrenia Schizophrenia [Schizophrenia]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
            Detailed Information Disease Link click to show the detail information of this Disease
         CA23: Asthma Asthma [Asthma]
            Detailed Information Disease Link click to show the detail information of this Disease
         DB93: Hepatic fibrosis or cirrhosis Cirrhotic [Hepatic fibrosis or cirrhosis]
            Detailed Information Disease Link click to show the detail information of this Disease
         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
            Detailed Information Disease Link click to show the detail information of this Disease
         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD2B: Syndromes with premature ageing appearance as a major feature Premature aging diseases [Syndromes with premature ageing appearance as a major feature]
            Detailed Information Disease Link click to show the detail information of this Disease
         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
            Detailed Information Disease Link click to show the detail information of this Disease
         MG30: Chronic pain Fibromyalgia [Chronic pain]
            Detailed Information Disease Link click to show the detail information of this Disease
         SD86: Dementia disorder Dementia [Dementia disorder]
            Detailed Information Disease Link click to show the detail information of this Disease
         XB8M: Congenital Melanoma [Congenital]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH1E13: Germinoma Germinoma [Germinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH3DV3: Adenoma Adenoma [Adenoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH5QN3: Nephroblastoma Wilms tumor [Nephroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH68V1: Liver cell adenoma Hepatocellular adenoma [Liver cell adenoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH98Z3: Schwannoma Schwannoma [Schwannoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
            Detailed Information Disease Link click to show the detail information of this Disease
         ZERO(Not Found): Sex chromosome anomalies X-chromosome inactivation (XCI) [Sex chromosome anomalies]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: K3
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Vitamin K3 may be inhibit histone deacetylase 6 (HDAC6).
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Valerate has been shown to hypermethylate HDAC6 CpG site in breast cancer cells.
  Metabolite Name: Bleomycin
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Bleomycin has been shown to promote the expression of histone deacetylase 6.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
Lipopolysaccharide has an enormous influence on histone deacetylase 6 activities.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Histone Deacetylases Promote ER Stress Induced Epithelial Mesenchymal Transition in Human Lung Epithelial Cells. Cell Physiol Biochem. 2018;46(5):1821-1834. doi: 10.1159/000489367. Epub 2018 Apr 25.
4 Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking Curr Top Med Chem. 2016;16(15):1705-16. doi: 10.2174/1568026616666151012111046.
5 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
6 Dietary proline supplementation alters colonic luminal microbiota and bacterial metabolite composition between days 45 and 70 of pregnancy in Huanjiang mini-pigs J Anim Sci Biotechnol. 2018 Jan 30;9:18. doi: 10.1186/s40104-018-0233-5. eCollection 2018.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.