Details of Microbe Species (MIC)

General Information of MIC (ID: MC0940)
  MIC Name
Bacteroides fragilis
  Synonym
Fusiformis fragilis
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
5188967
  No. of Coding Genes
4381
  No. of Non-Coding Genes
80
  No. of Small Non-Coding Genes
80
  No. of Gene Transcripts
4461
  No. of Base Pairs
5469625
  Description
Bacteroides fragilis is an obligately anaerobic, gram-negative, rod-shaped bacteria. It is part of the normal microbiota of the human colon and is generally commensal, but can cause infection if displaced into the bloodstream or surrounding tissue following surgery, disease or trauma.
  External Links Taxonomy ID 817
GutMDisorder ID gm0082
Genome Assembly ID DCMOUH0085B_1.0
GOLD Database ID Go0004681
GIMICA ID MIC00158

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Fatty acids
           Metabolite Name: Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Propionylation H3 EM Info Primary myocytes lysine 23 Health [3], [4]
Histone Propionylation H3K23 EM Info C2C12 cells Myod . [3], [4]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [5]
DNA Methylation DNMT3B EM Info . . . [1], [5]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [5], [6]
Histone Acetylation H4 EM Info . . . [1], [5]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [5], [7]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [5], [6]
Histone Deacetylation HDAC6 EM Info . . . [1], [5]
Histone Deacetylation HDAC7 EM Info . . . [1], [5]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [5], [7]
     Molecule Type: Phenolic compounds
           Metabolite Name: Phenolic acid Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [8], [9]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
3 Propionate hampers differentiation and modifies histone propionylation and acetylation in skeletal muscle cells. Mech Ageing Dev. 2021 Jun;196:111495. doi: 10.1016/j.mad.2021.111495. Epub 2021 Apr 28.
4 Species Deletions from Microbiome Consortia Reveal Key Metabolic Interactions between Gut Microbes mSystems. 2019 Jul 16;4(4):e00185-19. doi: 10.1128/mSystems.00185-19.
5 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
6 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
7 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
8 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
9 Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils J Biomed Sci. 2012 Oct 12;19(1):89. doi: 10.1186/1423-0127-19-89.

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