Details of Microbe Species (MIC)

General Information of MIC (ID: MC0933)
  MIC Name
Bacteroides ovatus
  Synonym
Pasteurella ovata
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
6290059
  No. of Coding Genes
5216
  No. of Non-Coding Genes
62
  No. of Small Non-Coding Genes
62
  No. of Gene Transcripts
5278
  No. of Base Pairs
6290059
  Description
Bacteroides ovatus is an obligate anaerobic, gram-negative common human gut bacteria. It is part of the normal human gut flora, however it is the least common of the Bacteroides intestinal isolates. It has also been associated with Coeliac disease.
  External Links Taxonomy ID 28116
GutMDisorder ID gm0084
Genome Assembly ID ASM157857v1
GOLD Database ID Go0000892
GIMICA ID MIC00167

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Isoflavonoids
           Metabolite Name: equol Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation BRCA2 EM Info MCF-7 cells promoter Breast cancer [1], [3]
DNA Methylation BRCA2 EM Info MDA-MB-231 cells promoter Breast cancer [1], [3]
DNA Methylation BRCA1 EM Info MCF-7 cells promoter Breast cancer [1], [3]
DNA Methylation BRCA1 EM Info MDA-MB-231 cells promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MCF-7 cells P300 promoter Breast cancer [4], [5]
Histone Acetylation H3K4 EM Info MCF-7 cells ER-alpha promoter Breast cancer [4], [6]
Histone Acetylation H4K8 EM Info MCF-7 cells ER-alpha promoter Breast cancer [4], [6]
Histone Acetylation H4K8 EM Info MCF-7 cells ER-BETA promoter Breast cancer [6], [7]
Histone Acetylation H3K4 EM Info MCF-7 cells ER-BETA promoter Breast cancer [6], [8]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells P300 promoter Breast cancer [1], [2]
Histone Acetylation H3K4 EM Info MCF-7 cells BRCA1 promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MCF-7 cells EZH2 promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MCF-7 cells SRC3 promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells BRCA1 promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells ER-alpha promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells ER-BETA promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells EZH2 promoter Breast cancer [1], [3]
Histone Acetylation H3K4 EM Info MDA-MB-231 cells SRC3 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MCF-7 cells BRCA1 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MCF-7 cells EZH2 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MCF-7 cells P300 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MCF-7 cells SRC3 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells BRCA1 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells ER-alpha promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells ER-BETA promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells EZH2 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells P300 promoter Breast cancer [1], [3]
Histone Acetylation H4K8 EM Info MDA-MB-231 cells SRC3 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MCF-7 cells ER-alpha promoter Breast cancer [4], [6]
Histone Trimethylation H3K27 EM Info MCF-7 cells ER-BETA promoter Breast cancer [4], [6]
Histone Trimethylation H3K9 EM Info MCF-7 cells ER-alpha promoter Breast cancer [4], [6]
Histone Trimethylation H3K27 EM Info MCF-7 cells P300 promoter Breast cancer [6], [7]
Histone Trimethylation H3K9 EM Info MCF-7 cells ER-BETA promoter Breast cancer [6], [8]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells P300 promoter Breast cancer [1], [2]
Histone Trimethylation H3K27 EM Info MCF-7 cells BRCA1 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MCF-7 cells EZH2 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MCF-7 cells SRC3 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells BRCA1 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells ER-alpha promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells ER-BETA promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells EZH2 promoter Breast cancer [1], [3]
Histone Trimethylation H3K27 EM Info MDA-MB-231 cells SRC3 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MCF-7 cells BRCA1 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MCF-7 cells EZH2 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MCF-7 cells P300 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MCF-7 cells SRC3 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells BRCA1 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells ER-alpha promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells ER-BETA promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells EZH2 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells P300 promoter Breast cancer [1], [3]
Histone Trimethylation H3K9 EM Info MDA-MB-231 cells SRC3 promoter Breast cancer [1], [3]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [1], [3]
DNA Methylation DNMT3A EM Info . . . [1], [3]
DNA Methylation DNMT3B EM Info . . . [1], [3]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [1], [3]
Histone Acetylation H4 EM Info . . . [1], [3]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [1], [3]
Histone Deacetylation HDAC6 EM Info . . . [1], [3]
Histone Deacetylation HDAC7 EM Info . . . [1], [3]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [1], [2]


References
1 Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production. Nutrients. 2019 Feb 19;11(2):433. doi: 10.3390/nu11020433.
2 Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines. Br J Nutr. 2012 Oct;108(7):1187-93. doi: 10.1017/S000711451100657X. Epub 2012 Jan 5.
3 Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics. 2013 Feb;5(1):51-63. doi: 10.2217/epi.12.74.
4 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
5 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
6 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
7 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
8 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.

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