Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10066)
  Official Symbol
BRCA1
  Official Full Name
breast cancer 1, early onset
  Synonym
BRCAI;BRCC1;BROVCA1;IRIS;PNCA4;PPP1R53;PSCP;RNF53
  Molecule Type
Protein coding
  Position On Chromosome
chr17(Start:41196312 - End:41277500)
  Strand
-
  Uniprot Entry
P38398 
  Dnmivd Disease
UCEC 
Metabolite(s) with this epigenetic modification
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Equol has been shown to decrease the methylation of the cytosine phosphate guanine (CpG) islands in the promoters of BRCA1 in MCF-7 cells.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Equol has been shown to decrease the methylation of the cytosine phosphate guanine (CpG) islands in the promoters of BRCA1 in MDA-MB-231 cells.

References
1 Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production. Nutrients. 2019 Feb 19;11(2):433. doi: 10.3390/nu11020433.
2 Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics. 2013 Feb;5(1):51-63. doi: 10.2217/epi.12.74.

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