Details of Microbe Species (MIC)

General Information of MIC (ID: MC0857)
  MIC Name
Lactobacillus reuteri
  Synonym
Lactobacillus fermentum subsp. reuteri
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
  Oxygen Sensitivity
Facultative anaerobe
  Microbial Metabolism
Saccharolytic; Respiratory or Fermentative
  Gram
Positive
  Host Relationship
Probiotic
  Genome Size (bp)
1999618
  No. of Coding Genes
1767
  No. of Non-Coding Genes
85
  No. of Small Non-Coding Genes
85
  No. of Gene Transcripts
1852
  No. of Base Pairs
2066054
  Description
Lactobacillus reuteri is a facultative anaerobic, gram-positive bacteria that naturally inhabits the gut of mammals and birds.
  External Links Taxonomy ID 1598
GutMDisorder ID gm0407
Genome Assembly ID LTH2584
GOLD Database ID Go0003512
GIMICA ID MIC00731

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Ethionine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Ethylation H3 EM Info THP-1 cells lysine 36 . [1], [2]
Histone Ethylation H3 EM Info THP-1 cells lysine 9 . [1], [2]
     Molecule Type: Polyamines
           Metabolite Name: Spermidine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3 EM Info Dermal fibroblasts MMP-2 . [3], [2]
Histone Deacetylation HDAC1 EM Info Dermal fibroblasts MMP-2 . [4]
Histone Deacetylation SIRT1 EM Info Dermal fibroblasts MMP-2 . [4]
Histone Demethylation LSD1 EM Info . . . [5], [6]
     Molecule Type: Vitamins
           Metabolite Name: Folate (B9) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Methylation H3K27 EM Info . Hes1 promoter . [1], [6]
Histone Methylation H3K27 EM Info . Neurog2 promoter . [1], [2]
miRNA miR-10A EM Info . . . [1], [7]
           Metabolite Name: Pyridoxine (B6) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation Mlh1 EM Info Lymphocytes promoter Colon and rectal cancer [5], [6]
           Metabolite Name: Riboflavin (B2) Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation Zac1 EM Info . . . [5], [6]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Biosynthesis of Vitamins by Probiotic Bacteria.
3 Associations of dietary methyl donor intake with MLH1 promoter hypermethylation and related molecular phenotypes in sporadic colorectal cancer. Carcinogenesis. 2008 Sep;29(9):1765-73. doi: 10.1093/carcin/bgn074. Epub 2008 Mar 13.
4 Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation. FASEB J. 2019 Mar;33(3):3536-3548. doi: 10.1096/fj.201801848R. Epub 2018 Nov 19.
5 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
6 Human Breast Milk Promotes the Secretion of Potentially Beneficial Metabolites by Probiotic Lactobacillus reuteri DSM 17938 Nutrients. 2019 Jul 9;11(7):1548. doi: 10.3390/nu11071548.
7 Metabolic engineering of lactic acid bacteria for the production of industrially important compounds Comput Struct Biotechnol J. 2012 Oct 29;3:e201210003. doi: 10.5936/csbj.201210003. eCollection 2012.

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