Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10039)
  Official Symbol
KDM1A
  Official Full Name
Lysine-specific histone demethylase 1A
  Synonym
AOF2;BHC110;KDM1;KIAA0601;LSD1
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:23019443 - End:23083689)
  Strand
+
  Uniprot Entry
O60341 
  ENSG ID
ENSG00000004487 
  Dnmivd Disease
READ 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Putrescine
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Putrescine could be inhibit LSD1 (lysine-specific histone demethylase 1).
  Metabolite Name: Spermidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [3], [4]
     Description
Spermidine could be inhibit LSD1 (lysine-specific histone demethylase 1).

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
4 Human Breast Milk Promotes the Secretion of Potentially Beneficial Metabolites by Probiotic Lactobacillus reuteri DSM 17938 Nutrients. 2019 Jul 9;11(7):1548. doi: 10.3390/nu11071548.

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