Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM10063)
  Official Symbol
HAT1
  Official Full Name
histone acetyltransferase 1
  Synonym
KAT1
  Molecule Type
Protein coding
  Position On Chromosome
chr2(Start:172778958 - End:172848599)
  Strand
+
  Uniprot Entry
O14929 
  ENSG ID
ENSG00000128708 
  Dnmivd Disease
HNSC 
Metabolite(s) with this epigenetic modification
  Metabolite Name: Hexanoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Hexanoate has been shown to activate histone acetylase.
  Metabolite Name: Branched-chain fatty acids (BCFAs)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Branched SCFAs (BCFAs) has been shown to activate histone acetylase.
  Metabolite Name: Caproate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Caproate has been shown to activate histone acetylase.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Benzoate has been shown to inhibit histone acetylase.
  Metabolite Name: Hydroxyphenylpropanoic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Hydroxyphenylpropanoic acid has been shown to inhibit histone acetylase.
  Metabolite Name: Pyridoxine (B6)
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Pyridoxine (B6) has been shown to activate histone acetylase.
  Metabolite Name: Vitamin K
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [4]
     Description
Vitamin K has been shown to activate histone acetylase.
  Metabolite Name: urolithin A
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
urolithin A could inhibit TNF-alpha-mediated induction of histone acetyltransferases (HAT) activity in THP-1 human monocytes.
  Metabolite Name: urolithin B
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
urolithin B could inhibit TNF-alpha-mediated induction of histone acetyltransferases (HAT) activity in THP-1 human monocytes.
  Metabolite Name: urolithin C
     Detailed Information Meta Info click to show the detail information of this Metabolite [6], [7]
     Description
urolithin C could inhibit TNFalpha-mediated induction of histone acetyltransferases (HAT) activity in THP-1 human monocytes.
  Metabolite Name: Hydroxicinnamic acid
     Detailed Information Meta Info click to show the detail information of this Metabolite [8], [9]
     Description
Hydroxicinnamic acid has been shown to inhibit histone acetylase.

References
1 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
2 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
3 Holocarboxylase synthetase regulates expression of biotin transporters by chromatin remodeling events at the SMVT locus. J Nutr Biochem. 2008 Jun;19(6):400-8. doi: 10.1016/j.jnutbio.2007.06.002. Epub 2007 Sep 27.
4 High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans. Clin Epigenetics. 2017 Jul 24;9:74. doi: 10.1186/s13148-017-0374-y. eCollection 2017.
5 Impact of dietary gut microbial metabolites on the epigenome. Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748):20170359. doi: 10.1098/rstb.2017.0359.
6 Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500901. Epub 2016 Jun 20.
7 Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochem Biophys Rep. 2021 Jan 6;25:100891. doi: 10.1016/j.bbrep.2020.100891. eCollection 2021 Mar.
8 Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013 Dec 19;504(7480):446-50. doi: 10.1038/nature12721. Epub 2013 Nov 13.
9 Para-cresol production by Clostridium difficile affects microbial diversity and membrane integrity of Gram-negative bacteria PLoS Pathog. 2018 Sep 12;14(9):e1007191. doi: 10.1371/journal.ppat.1007191. eCollection 2018 Sep.

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