Details of Metabolite (Meta)

General Information of Metabolite (ID: MT107)
  Meta Name
urolithin C
  Unify Name
Urolithin C
  Synonym    Click to Show/Hide the Detailed Synonyms of This Metabolite
Urolithin-C;Urolithin C
  Molecule Type
Coumarins and derivatives
  Formula
C13H8O5
  Inchi Key
HHXMEXZVPJFAIJ-UHFFFAOYSA-N
  Description    Click to Show/Hide the Detailed Description of This Metabolite
Human Metabolome Database (HMDB): Urolithin C, also known as urolithin-C, belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one). Urolithin C is an extremely weak basic (essentially neutral) compound (based on its pKa).
  External Links   HMDB ID   HMDB0029218

The epigenetic modification information of this metabolite
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation HAT EM Info THP-1 cells . . [1], [2]

The microbes that produce this metabolite
      Gordonibacter urolithinfaciens
         Detailed Information MIC Info click to show the detail information of this Microbiota [1], [2]
         Description
Gordonibacter urolithinfaciens was isolated from human feces and is able to metabolize ellagic acid (a dietary phenolic compound present in various fruits) to urolithins.

References
1 Urolithins, the rescue of "old" metabolites to understand a "new" concept: Metabotypes as a nexus among phenolic metabolism, microbiota dysbiosis, and host health status. Mol Nutr Food Res. 2017 Jan;61(1). doi: 10.1002/mnfr.201500901. Epub 2016 Jun 20.
2 Ellagic acid and its fermentative derivative urolithin A show reverse effects on the gp91-phox gene expression, resulting in opposite alterations in all-trans retinoic acid-induced superoxide generating activity of U937 cells. Biochem Biophys Rep. 2021 Jan 6;25:100891. doi: 10.1016/j.bbrep.2020.100891. eCollection 2021 Mar.

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