Details of Microbe Species (MIC)

General Information of MIC (ID: MC1075)
  MIC Name
Helicobacter pylori SS1
  Synonym
Helicobacter pylori (strain SS1)
  Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
  Oxygen Sensitivity
Aerobe
  Microbial Metabolism
Saccharolytic; Respiratory
  Gram
Negative
  Host Relationship
Pathogen
  Description
Helicobacter pylori, previously known as Campylobacter pylori, is a gram-negative, microaerophilic, spiral bacteria usually found in the stomach. Its helical shape is thought to have evolved in order to penetrate the mucoid lining of the stomach and thereby establish infection.
  External Links Taxonomy ID 102617
GOLD Database ID Go0012061


Full List of Protein(s) Produced by This MIC
     Protein Type: Microbial secreted proteins
           Protein Name: CagA Click to Show/Hide
              Detailed Infomation Pro Info click to show the detail information of this protein
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation let-7 EM Info RGM1 cells promoter . [1], [2]
Histone Trimethylation H3 EM Info RGM1 cells lysine 27 . [1], [2]
miRNA miRNA-584 EM Info AGS cells . Helicobacter pylori infection [3], [2]
miRNA miRNA-1290 EM Info AGS cells . Helicobacter pylori infection [3], [2]
miRNA miR-373 EM Info AGS cells . Helicobacter pylori infection [4], [2]
miRNA miR-372 EM Info AGS cells . Helicobacter pylori infection [4], [2]
miRNA miR-371-3p EM Info AGS cells . Helicobacter pylori infection [4], [2]

References
1 CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis Gut. 2013 Nov;62(11):1536-46. doi: 10.1136/gutjnl-2011-301625. Epub 2012 Aug 30.
2 Lactobacillus fermentum UCO-979C strongly inhibited Helicobacter pylori SS1 in Meriones unguiculatus Benef Microbes. 2018 Jun 15;9(4):625-627. doi: 10.3920/BM2017.0160. Epub 2018 Apr 10.
3 MicroRNAs up-regulated by CagA of Helicobacter pylori induce intestinal metaplasia of gastric epithelial cells PLoS One. 2012;7(4):e35147. doi: 10.1371/journal.pone.0035147. Epub 2012 Apr 20.
4 Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression Silence. 2011 Oct 25;2(1):7. doi: 10.1186/1758-907X-2-7.

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