Details of Microbe Species (MIC)

General Information of MIC (ID: MC1272)
  MIC Name
Lactobacillus spp.
  Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Positive
  Host Relationship
Probiotic
  No. of Coding Genes
1954
  No. of Non-Coding Genes
26
  No. of Small Non-Coding Genes
26
  No. of Gene Transcripts
2070
  No. of Pseudogenes 90
  Description
Lactobacillus sp. is a bacteria of gram-positive, aerotolerant anaerobics or microaerophilic, rod-shaped, non-spore-forming bacteria.
  External Links Taxonomy ID 1591
GutMDisorder ID gm0412
Genome Assembly ID ASM345259v1
GOLD Database ID Go0575399
GIMICA ID MIC00701

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Fatty acids
           Metabolite Name: Acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [end-products]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Acetylation H3K9 EM Info HepG2 cells LDHA promoter Hypoxia [1], [2]
Histone Acetylation H3K27 EM Info HepG2 cells FASN promoter Hypoxia [3]
Histone Acetylation H3K27 EM Info HepG2 cells LDHA promoter Hypoxia [3]
Histone Acetylation H3K56 EM Info HepG2 cells FASN promoter Hypoxia [3]
Histone Acetylation H3K9 EM Info HepG2 cells ACACA promoter Hypoxia [3]
Histone Acetylation H4 EM Info Eosinophil cell Foxo3A promoter Asthma [3]
Histone Deacetylation HDAC9 EM Info Eosinophil cell . Asthma [3]
     Molecule Type: Tryptophan metabolites
           Metabolite Name: Indole Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [1], [2]
           Metabolite Name: Indole-3-acetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [4], [2]
           Metabolite Name: Indole-3-aldehyde Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [4], [2]
           Metabolite Name: Indole-3-carboxaldehyde Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [4], [2]
           Metabolite Name: Indole-3-Propionate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [4], [2]
           Metabolite Name: Kynurenine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells ARNT2 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells ASCL1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells AVP . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells BMP7 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CARTPT . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CCK . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CORT . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells CRH . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GALP . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GAST . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GHRH . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells GNRH2 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells HCRT . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells HMX2 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells KISS1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells LHX1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NKX2-1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPVF . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPW . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NPY . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells NR5A1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells OTP . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells OXT . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PDYN . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PENK . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PNOC . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells POMC . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells POU3F2 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells PRLH . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells RAX . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SHH . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SIM1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SIX3 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells SST . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells TRH . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells VAX1 . [3], [5]
Histone O-GlcNAcylation H2AS40 EM Info hiPSC-derived neural cells AGRP . [4], [2]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells AGRP . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells ARNT2 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells ASCL1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells AVP . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells BMP7 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CARTPT . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CCK . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CORT . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells CRH . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GALP . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GAST . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GHRH . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells GNRH2 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells HCRT . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells HMX2 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells KISS1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells LHX1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NKX2-1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPVF . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPW . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NPY . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells NR5A1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells OTP . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells OXT . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PDYN . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PENK . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PNOC . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells POMC . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells POU3F2 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells PRLH . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells RAX . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SHH . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SIM1 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SIX3 . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells SST . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells TRH . [3], [5]
Histone Trimethylation H3K4 EM Info hiPSC-derived neural cells VAX1 . [3], [5]
           Metabolite Name: Serotonin Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [others]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation SLC6A4 EM Info T cells promoter Health [3], [5]
           Metabolite Name: Tryptamine Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [intermediate]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT EM Info . . . [3], [6]


References
1 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
2 Antifungal Activity of Lactobacillus pentosusOCK 0979 in the Presence of Polyols and Galactosyl-Polyols Probiotics Antimicrob Proteins. 2018 Jun;10(2):186-200. doi: 10.1007/s12602-017-9344-0.
3 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
4 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
5 Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci. Sci Rep. 2019 Dec 24;9(1):19768. doi: 10.1038/s41598-019-56341-x.
6 Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression. PLoS One. 2012;7(6):e39501. doi: 10.1371/journal.pone.0039501. Epub 2012 Jun 20.

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