Details of Microbe Species (MIC)

General Information of MIC (ID: MC0935)
  MIC Name
Bacteroides vulgatus
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Bacteroidaceae
Genus: Bacteroides
  Oxygen Sensitivity
Anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
5165891
  No. of Coding Genes
4233
  No. of Non-Coding Genes
100
  No. of Small Non-Coding Genes
100
  No. of Gene Transcripts
4333
  No. of Base Pairs
5165891
  Description
Bacteroides vulgatus is an anaerobic, gram-negative among the most commonly isolated microbes from the human gastrointestinal tract, and it has been found to constitute part of the core gut microbiota in healthy humans. It is generally considered to be a beneficial gut commensal, but studies also suggest that important intraspecies variations may exist, with specific strains of B. vulgatus shown to be capable of promoting or protecting against colitis.
  External Links Taxonomy ID 821
GutMDisorder ID gm0089
Genome Assembly ID ASM141231v1
GOLD Database ID Go0487063
GIMICA ID MIC00186

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Amino acid (AAs)
           Metabolite Name: Phenylacetate Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial producted compound [precursors]
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
Histone Deacetylation HDAC EM Info . . . [1], [2]
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [3]
DNA Methylation DNMT3B EM Info . . . [1], [3]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [3], [4]
Histone Acetylation H4 EM Info . . . [1], [3]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [3], [4]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [5]
Histone Deacetylation HDAC6 EM Info . . . [1], [3]
Histone Deacetylation HDAC7 EM Info . . . [1], [3]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [5]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 p-Cresyl Sulfate. Toxins (Basel). 2017 Jan 29;9(2):52. doi: 10.3390/toxins9020052.
3 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
4 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
5 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.