Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00058)
  Official Symbol
HDAC1
  Official Full Name
histone deacetylase 1
  Synonym
GON-10;HD1;KDAC1;RPD3L1
  Molecule Type
Protein coding
  Position On Chromosome
chr1(Start:32292083 - End:32333635)
  Strand
+
  Uniprot Entry
Q13547 
  ENSG ID
ENSG00000116478 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         1B10: Tuberculosis of the respiratory system Tuberculosis (TB) [Tuberculosis of the respiratory system]
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         1F84: Opisthorchiasis Opisthorchis viverrini [Opisthorchiasis]
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         2A00: Primary neoplasms of brain Glioma [Primary neoplasms of brain]
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         2A00: Primary neoplasms of brain Oligodendroglial tumors [Primary neoplasms of brain]
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         2A01: Primary neoplasms of meninges Meningioma [Primary neoplasms of meninges]
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         2A3Z: Myelodysplastic syndromes Myelodysplastic syndrome [Myelodysplastic syndromes]
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         2A90: Mature T-cell lymphoma, specified types, nodal or systemic Anaplastic large cell lymphoma (ALCL) [Mature T-cell lymphoma, specified types, nodal or systemic]
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         2B50: Chondrosarcoma Central chondrosarcoma [Chondrosarcoma]
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         2B6B: Malignant neoplasms of nasopharynx Nasopharyngeal carcinoma (NPC) [Malignant neoplasms of nasopharynx]
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         2B6E: Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx Oral or pharyngeal squamous cell carcinoma (OPSCC) [Malignant neoplasms of other or ill-defined sites in the lip, oral cavity or pharynx]
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         2B70: Malignant neoplasms of oesophagus Barrett's esophagus and esophageal adenocarcinoma [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal adenocarcinoma (EAC) [Malignant neoplasms of oesophagus]
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         2B70: Malignant neoplasms of oesophagus Esophageal squamous cell carcinoma (ESCC) [Malignant neoplasms of oesophagus]
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         2B72: Malignant neoplasms of stomach Gastric cancer [Malignant neoplasms of stomach]
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         2B80: Malignant neoplasms of small intestine Small intestinal neuroendocrine tumours (SINETs) [Malignant neoplasms of small intestine]
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         2B90: Malignant neoplasms of colon Colon adenocarcinoma [Malignant neoplasms of colon]
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         2B90: Malignant neoplasms of colon Colorectal cancer [Malignant neoplasms of colon]
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         2C10: Malignant neoplasm of pancreas Pancreatic ductal adenocarcinoma (PDAC) [Malignant neoplasm of pancreas]
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         2C12: Malignant neoplasms of liver or intrahepatic bile ducts Liver cancer [Malignant neoplasms of liver or intrahepatic bile ducts]
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         2C25: Malignant neoplasms of bronchus or lung Lung adenocarcinoma [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Lung cancer [Malignant neoplasms of bronchus or lung]
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         2C25: Malignant neoplasms of bronchus or lung Non small cell lung cancer (NSCLC) [Malignant neoplasms of bronchus or lung]
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         2C30: Melanoma of skin Cutaneous Melanoma [Melanoma of skin]
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         2C60: Carcinoma of breast Breast cancer [Carcinoma of breast]
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         2C73: Malignant neoplasms of ovary Ovarian serous adenocarcinoma (OSA) [Malignant neoplasms of ovary]
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         2C82: Malignant neoplasms of prostate Prostate cancer [Malignant neoplasms of prostate]
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         2D10: Malignant neoplasms of thyroid gland Thyroid tumors [Malignant neoplasms of thyroid gland]
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         4A20: Acquired immunodeficiencies Immunodeficiency [Acquired immunodeficiencies]
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         4A40: Lupus erythematosus Systemic lupus erythematosus (SLE) [Lupus erythematosus]
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         5A02: Thyrotoxicosis Graves' disease [Thyrotoxicosis]
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         5B81: Obesity Obesity [Obesity]
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         6A00: Disorders of intellectual development Intellectual disability and congenital anomalies(ID/CA) [Disorders of intellectual development]
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         6A02: Autism spectrum disorder Autism [Autism spectrum disorder]
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         6A20: Schizophrenia Schizophrenia [Schizophrenia]
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         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
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         8A00: Parkinsonism Parkinson's disease (PD) [Parkinsonism]
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         8A01: Choreiform disorders Huntington's disease (HD) [Choreiform disorders]
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         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
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         8A40: Multiple sclerosis Multiple sclerosis [Multiple sclerosis]
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         9A01: Infectious disorders of eyelid Human eye and its diseases [Infectious disorders of eyelid]
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         BD40: Atherosclerotic chronic arterial occlusive disease Atherosclerosis [Atherosclerotic chronic arterial occlusive disease]
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         CA22: Chronic obstructive pulmonary disease Chronic obstructive pulmonary disease (COPD) [Chronic obstructive pulmonary disease]
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         CA23: Asthma Asthma [Asthma]
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         CB03: Idiopathic interstitial pneumonitis Idiopathic pulmonary fibrosis (IPF) [Idiopathic interstitial pneumonitis]
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         DB92: Non-alcoholic fatty liver disease Nonalcoholic fatty liver disease (NAFLD) [Non-alcoholic fatty liver disease]
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         DD70: Crohn disease Crohn's disease [Crohn disease]
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         EE60: Keloid or hypertrophic scars Keloid [Keloid or hypertrophic scars]
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         FA0Z: Osteoarthritis Osteoarthritis (OA) [Osteoarthritis]
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         FA20: Rheumatoid arthritis Rheumatoid arthritis [Rheumatoid arthritis]
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         FA21: Psoriatic arthritis Psoriatic [Psoriatic arthritis]
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         GA10: Endometriosis Endometriosis [Endometriosis]
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         JA24: Pre-eclampsia Preeclampsia (PE) [Pre-eclampsia]
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         KA21: Disorders of newborn related to short gestation or low birth weight Preterm birth [Disorders of newborn related to short gestation or low birth weight]
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         LA02: Spina bifida Neural tube defects (NTDs) [Spina bifida]
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         LA4Z: Clefts of lip, alveolus or palate Non-syndromic cleft lip and palate [Clefts of lip, alveolus or palate]
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         LD2B: Syndromes with premature ageing appearance as a major feature Premature aging diseases [Syndromes with premature ageing appearance as a major feature]
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         LD2C: Overgrowth syndromes Sotos syndrome(SS) [Overgrowth syndromes]
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         LD2F: Syndromes with multiple structural anomalies, without predominant body system involvement Silver russell syndrome [Syndromes with multiple structural anomalies, without predominant body system involvement]
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         LD40: Complete trisomies of the autosomes Down syndrome (DS) [Complete trisomies of the autosomes]
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         LD44: Deletions of the autosomes Deletion or duplication of chromosome 7q11.23 [Deletions of the autosomes]
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         MG22: Fatigue Chronic fatigue syndrome (CFS) [Fatigue]
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         SD86: Dementia disorder Dementia [Dementia disorder]
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         SE30: Developmental delay disorder CHARGE and Kabuki syndromes [Developmental delay disorder]
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         XB1Y: Familial Familial recurrent moles (RHM) [Familial]
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         XB8M: Congenital Melanoma [Congenital]
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         XH0945: Squamous cell carcinoma Head and neck squamous cell cancer (HNSCC) [Squamous cell carcinoma]
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         XH1E13: Germinoma Germinoma [Germinoma]
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         XH1XF3: Osteosarcoma Osteosarcoma [Osteosarcoma]
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         XH3DV3: Adenoma Adenoma [Adenoma]
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         XH4546: Signet ring cell carcinoma Signet ring cell colorectal cancer [Signet ring cell carcinoma]
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         XH46F1: Clear cell renal cell carcinoma Clear cell renal cell carcinoma (ccRCC) [Clear cell renal cell carcinoma]
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         XH4S92: Leukaemia Leukemia [Leukaemia]
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         XH4V32: Ductal carcinoma in situ Ductal carcinoma in situ (DCIS) [Ductal carcinoma in situ]
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         XH4W48: Hepatocellular carcinoma Hepatocellular carcinoma (HCC) [Hepatocellular carcinoma]
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         XH4XG8: Chronic myeloid leukaemia Chronic Phase-Chronic Myeloid Leukemia [Chronic myeloid leukaemia]
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         XH68V1: Liver cell adenoma Hepatocellular adenoma [Liver cell adenoma]
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         XH6PH6: Astrocytoma Astrocytoma [Astrocytoma]
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         XH74S1: Adenocarcinoma Small bowel adenocarcinoma [Adenocarcinoma]
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         XH7F82: Glioblastoma Glioblastoma [Glioblastoma]
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         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic leukemia [Lymphocytic leukaemia]
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         XH7ZQ4: Atypical teratoid/rhabdoid tumour Atypical teratoid/rhabdoid tumor (ATRT) [Atypical teratoid/rhabdoid tumour]
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         XH85Z0: Neuroblastoma Neuroblastoma [Neuroblastoma]
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         XH8844: Oligodendroglioma, anaplastic Anaplastic oligodendrogliomas/oligoastrocytomas [Oligodendroglioma, anaplastic]
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         XH8AA5: Acute myeloid leukaemia Acute myeloid leukemia (AML) [Acute myeloid leukaemia]
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         XH8D74: Carcinomatosis Cancer [Carcinomatosis]
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         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
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         XH8P29: Medulloblastoma Primary medulloblastoma [Medulloblastoma]
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         XH94U0: Pituitary adenoma Nonfunctioning pituitary adenomas [Pituitary adenoma]
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         XH98Z3: Schwannoma Schwannoma [Schwannoma]
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         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors (GIST) [Gastrointestinal stromal tumour]
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         XN3DY: Helicobacter pylori Helicobacter pylori infection [Helicobacter pylori]
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         XN487: Human immunodeficiency virus Human immunodeficiency virus (HIV) [Human immunodeficiency virus]
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         ZERO(Not Found): Acute mania and inflammatory Acute mania and inflammatory [Acute mania and inflammatory]
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Metabolite(s) with this epigenetic modification
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1]
     Description
Valerate has been shown to inhibit histone deacetylase 1 (HDAC1).
  Metabolite Name: Spermine
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [3]
     Description
Spermine could increase the expression levels of HDAC1 in HT1080 cells.
  Metabolite Name: Hydroxycoumarin
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [5]
     Description
Hydroxycoumarin has been shown to reduce the expression of HDAC1
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [4], [6]
     Description
Butyrate has been shown to inhibit histone deacetylase
  Metabolite Name: Flagellin
     Detailed Information Meta Info click to show the detail information of this Metabolite [7]
     Description
Flagellin could be decrease histone deacetylase 1(HDAC1).
  Metabolite Name: 2-Aminoacetophenone
     Detailed Information Meta Info click to show the detail information of this Metabolite [8]
     Description
2-Aminoacetophenone could modulates the HAT/HDAC activity and promotes HDAC1 accumulation.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [9]
     Description
Lipopolysaccharide (LPS) could significantly down-regulated the expression of Histone deacetylase HDAC1.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [10], [11]
     Description
Valerate has been shown to inhibite HDAC1.
  Metabolite Name: Spermidine
     Detailed Information Meta Info click to show the detail information of this Metabolite [12], [13]
     Description
Spermidine could increase the expression levels of histone deacetylase 1 (HDAC1).

References
1 Human gut bacteria as potent class I histone deacetylase inhibitors in vitro through production of butyric acid and valeric acid. PLoS One. 2018 Jul 27;13(7):e0201073. doi: 10.1371/journal.pone.0201073. eCollection 2018.
2 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
3 Activation of p53 by spermine mediates induction of autophagy in HT1080 cells. Int J Biol Macromol. 2014 Feb;63:56-63. doi: 10.1016/j.ijbiomac.2013.10.041. Epub 2013 Nov 1.
4 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
5 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
6 Phenylbutyrate and phenylacetate induce differentiation and inhibit proliferation of human medulloblastoma cells. Clin Cancer Res. 2004 Feb 1;10(3):1150-9. doi: 10.1158/1078-0432.ccr-0747-3.
7 Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression J Immunol. 2008 Jul 15;181(2):940-7. doi: 10.4049/jimmunol.181.2.940.
8 [Advances in oral bacteria influencing host epigenetic regulation]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2020 Oct 1;38(5):583-588. doi: 10.7518/hxkq.2020.05.019.
9 Short-chain fatty acids from periodontal pathogens suppress histone deacetylases, EZH2, and SUV39H1 to promote Kaposi's sarcoma-associated herpesvirus replication. J Virol. 2014 Apr;88(8):4466-79. doi: 10.1128/JVI.03326-13. Epub 2014 Feb 5.
10 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
11 Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract J Clin Med. 2019 Jul 24;8(8):1090. doi: 10.3390/jcm8081090.
12 Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs. Int J Biol Macromol. 2012 Dec;51(5):1003-7. doi: 10.1016/j.ijbiomac.2012.08.013. Epub 2012 Aug 25.
13 Stages of pregnancy and weaning influence the gut microbiota diversity and function in sows J Appl Microbiol. 2019 Sep;127(3):867-879. doi: 10.1111/jam.14344. Epub 2019 Jul 1.

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