Details of Epigenetic Molecule(EM)

General Information of EM (ID: EM00030)
  Official Symbol
HIST1H4A
  Official Full Name
histone cluster 1, H4a
  Synonym
FO108;H4;H4.k;H4/A;H4/I;H4/b;H4/c;H4/d;H4/e;H4/g;H4/h;H4/j;H4/k;H4/m;H4/n;H4/o;H4/p;H4F2;H4F2iii;H4F2iv;H4FA;H4FB;H4FC;H4FD;H4FE;H4FG;H4FH;H4FI;H4FJ;H4FK;H4FM;H4FN;H4M;HIST1H4L;HIST2H4;dJ160A22.1;dJ160A22.2;dJ221C16.1;dJ221C16.9
  Molecule Type
Protein coding
  Position On Chromosome
chr6(Start:26021907 - End:26022278)
  Strand
+
  Uniprot Entry
P62805 
  ENSG ID
ENSG00000196176 
  Dnmivd Disease
LUSC 
    Disease Relevance (Click to Show/Hide)
         5B81: Obesity Obesity [Obesity]
            Detailed Information Disease Link click to show the detail information of this Disease
         6E8Z: Mental, behavioural or neurodevelopmental disorders Psychiatric disorders [Mental, behavioural or neurodevelopmental disorders]
            Detailed Information Disease Link click to show the detail information of this Disease
         8A20: Alzheimer disease Alzheimer's disease [Alzheimer disease]
            Detailed Information Disease Link click to show the detail information of this Disease
         XB8M: Congenital Melanoma [Congenital]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH7PW5: Lymphocytic leukaemia Pediatric acute lymphoblastic [Lymphocytic leukaemia]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH8P29: Medulloblastoma Medulloblastoma [Medulloblastoma]
            Detailed Information Disease Link click to show the detail information of this Disease
         XH9HQ1: Gastrointestinal stromal tumour Gastrointestinal stromal tumors [Gastrointestinal stromal tumour]
            Detailed Information Disease Link click to show the detail information of this Disease
Metabolite(s) with this epigenetic modification
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [2]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8acat the promoter of ER-alpha.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [3]
     Description
Lipopolysaccharide has been shown to induce histone H4 acetylation.
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [1], [4]
     Description
Acetate has been shown to result in the increase in histone H4 acetylation
  Metabolite Name: Acetate
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [6]
     Description
Acetate has been shown to increase acetylation of the histone H4 at the Foxp3 promoter.
  Metabolite Name: Butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [5], [4]
     Description
Butyrate has been shown to result in the increase in histone H4 acetylation
  Metabolite Name: Iso-butyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [7], [8]
     Description
isobutyrate couldincreased lysine isobutyrylation levels on histones H4 at lysine.
  Metabolite Name: Propionate
     Detailed Information Meta Info click to show the detail information of this Metabolite [9]
     Description
Propionate has been shown to result in the increase in histone H4 acetylation
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Benzoate has been shown to enhance the H4K16 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Benzoate has been shown to enhance the H4K8 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Benzoate has been shown to enhance the H4K5 benzoylation levels in HepG2 cells.
  Metabolite Name: Benzoate
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Benzoate has been shown to enhance the H4K12 benzoylation levels in HepG2 cells.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Biotinylation is an epigenetic process in which gene expression is repressed by covalent attachment of biotin on histone H4 at K8
  Metabolite Name: Niacin (B3)
     Detailed Information Meta Info click to show the detail information of this Metabolite [9], [10]
     Description
Niacin (B3) could increase histone H4 acetylation at the FXN gene in friedreich's ataxia.
  Metabolite Name: Biotin (B7)
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [11]
     Description
Biotin (B7) has been shown to increase the level of K12Bio H4 at SMVT promoter 1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [11]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8ac at the promoter of ER-BETA.
  Metabolite Name: Lipopolysaccharide
     Detailed Information Meta Info click to show the detail information of this Metabolite [2], [11]
     Description
Lipopolysaccharide has been shown to induce histone H4 acetylation.
  Metabolite Name: Flagellin
     Detailed Information Meta Info click to show the detail information of this Metabolite [12]
     Description
Legionella pneumophila-induced acetylation of H4 at the IL-8 promoter depended on flagellin.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8acat the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of BRCA1.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of ER-alpha.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of ER-BETA.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8acat the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of EZH2.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8acat the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of P300.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increaserepressive histone marks such as H4K8acat the promoter of SRC3.
  Metabolite Name: equol
     Detailed Information Meta Info click to show the detail information of this Metabolite [13], [14]
     Description
Equol has been shown to increase repressive histone marks such as H4K8ac at the promoter of SRC3.
  Metabolite Name: Valerate
     Detailed Information Meta Info click to show the detail information of this Metabolite [15], [4]
     Description
Valerate has been shown to result in the increase in histone H4 acetylation
  Metabolite Name: Phenylbutyrate
     Detailed Information Meta Info click to show the detail information of this Metabolite [16], [17]
     Description
Phenylbutyrate has been shown to induce increased histones H4 acetylation in D283-MED cells.

Protein(s) with this epigenetic modification
  Protein Name: NuE
     Detailed Information Pro Info click to show the detail information of this protein [18]
     Description
NuE could methylates H4.
  Protein Name: Listeriolysin O
     Detailed Information Pro Info click to show the detail information of this protein [19]
     Description
Listeriolysin O(LLO) has been shown to induce a drastic deacetylation of H4.
  Protein Name: Rv3763
     Detailed Information Pro Info click to show the detail information of this protein [20]
     Description
Rv3763 could inhibite the increased acetylation of histones H4 at CIITA pIV locus.

References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
3 Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family EMBO J. 2011 May 18;30(10):1977-89. doi: 10.1038/emboj.2011.94. Epub 2011 Apr 5.
4 The Virtual Metabolic Human database: integrating human and gut microbiome metabolism with nutrition and disease. Nucleic Acids Res. 2019 Jan 8;47(D1):D614-D624. doi: 10.1093/nar/gky992.
5 Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Nat Commun. 2015 Jun 23;6:7320. doi: 10.1038/ncomms8320.
6 Glycine Cleavage Powers Photoheterotrophic Growth of Chloroflexus aurantiacus in the Absence of H 2 Front Microbiol. 2015 Dec 22;6:1467. doi: 10.3389/fmicb.2015.01467. eCollection 2015.
7 Crosstalk between the microbiome and epigenome: messages from bugs. J Biochem. 2018 Feb 1;163(2):105-112. doi: 10.1093/jb/mvx080.
8 Blood Pressure Abnormalities Associated with Gut Microbiota-Derived Short Chain Fatty Acids in Children with Congenital Anomalies of the Kidney and Urinary Tract J Clin Med. 2019 Jul 24;8(8):1090. doi: 10.3390/jcm8081090.
9 Gut Microbiota as Important Mediator Between Diet and DNA Methylation and Histone Modifications in the Host. Nutrients. 2020 Feb 25;12(3):597. doi: 10.3390/nu12030597.
10 Arachidonic and oleic acid exert distinct effects on the DNA methylome. Epigenetics. 2016 May 3;11(5):321-34. doi: 10.1080/15592294.2016.1161873. Epub 2016 Apr 18.
11 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.
12 Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression J Immunol. 2008 Jul 15;181(2):940-7. doi: 10.4049/jimmunol.181.2.940.
13 Daidzein Intake Is Associated with Equol Producing Status through an Increase in the Intestinal Bacteria Responsible for Equol Production. Nutrients. 2019 Feb 19;11(2):433. doi: 10.3390/nu11020433.
14 Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines. Epigenomics. 2013 Feb;5(1):51-63. doi: 10.2217/epi.12.74.
15 Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia. Nat Commun. 2016 Jun 30;7:11960. doi: 10.1038/ncomms11960.
16 Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells. 2010 Apr;28(4):713-20. doi: 10.1002/stem.402.
17 Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity World J Gastroenterol. 2006 Feb 21;12(7):1071-7. doi: 10.3748/wjg.v12.i7.1071.
18 Histone methylation by NUE, a novel nuclear effector of the intracellular pathogen Chlamydia trachomatis PLoS Pathog. 2010 Jul 15;6(7):e1000995. doi: 10.1371/journal.ppat.1000995.
19 Histone modifications induced by a family of bacterial toxins Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13467-72. doi: 10.1073/pnas.0702729104. Epub 2007 Aug 3.
20 Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signaling. J Immunol. 2006 Apr 1;176(7):4323-30. doi: 10.4049/jimmunol.176.7.4323.

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