Details of Microbe Species (MIC)

General Information of MIC (ID: MC1217)
  MIC Name
Alistipes
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidia
Family: Rikenellaceae
Genus: Alistipes
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Weakly saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Description
Alistipes is classified as gram-negative, rod-shaped, anaerobic, and non-spore forming.
  External Links Taxonomy ID 239759
GutMDisorder ID gm0035

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [2]
DNA Methylation DNMT3B EM Info . . . [1], [2]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [2], [3]
Histone Acetylation H4 EM Info . . . [1], [2]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [2], [4]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [2], [3]
Histone Deacetylation HDAC6 EM Info . . . [1], [2]
Histone Deacetylation HDAC7 EM Info . . . [1], [2]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [2], [4]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
3 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
4 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

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