Details of Microbe Species (MIC)

General Information of MIC (ID: MC1030)
  MIC Name
Prevotella copri
  Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Prevotellaceae
Genus: Prevotella
  Oxygen Sensitivity
Obligate anaerobe
  Microbial Metabolism
Saccharolytic; Fermentative
  Gram
Negative
  Host Relationship
Commensal
  Genome Size (bp)
3507873
  Description
Prevotella copri is a gram-negative bacteria. The cells are anaerobic and do not form spores. Prevotella copri is an intestinal bacteria, and its anaerobic qualities allows it to grow successfully in the human gut and intestines. This bacteria was found associated with Inflammatory bowel disease.
  External Links Taxonomy ID 165179
GutMDisorder ID gm0536
GOLD Database ID Go0489250
GIMICA ID MIC01010

Full List of Metabolite(s) Produced by This MIC
     Molecule Type: Microbial cell components
           Metabolite Name: Lipopolysaccharide Click to Show/Hide
              Detailed Infomation Meta Info click to show the detail information of this Metabolite
              Metabolic Classification Microbial cell components
Modification Type Molecule EM Info Cell/Tissue Type Modified sites Condition REF
DNA Methylation DNMT3A EM Info . . . [1], [2]
DNA Methylation DNMT3B EM Info . . . [1], [2]
DNA Methylation DNMT1 EM Info Oral epithelial cells . Periodontitis [2], [3]
Histone Acetylation H4 EM Info . . . [1], [2]
Histone Acetylation Histone EM Info TGF-beta1 cells lysine 9 . [2], [4]
Histone Acetylation H3 EM Info Oral epithelial cells lysine 9 Periodontitis [2], [3]
Histone Deacetylation HDAC6 EM Info . . . [1], [2]
Histone Deacetylation HDAC7 EM Info . . . [1], [2]
Histone Phosphorylation Histone EM Info TGF-beta1 cells serine 10 . [2], [4]


References
1 Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals. Nutr Rev. 2017 May 1;75(5):374-389. doi: 10.1093/nutrit/nux001.
2 Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling mSystems. 2017 Nov 14;2(6):e00046-17. doi: 10.1128/mSystems.00046-17. eCollection 2017 Nov-Dec.
3 Epigenetic Modifications of Histones in Periodontal Disease. J Dent Res. 2016 Feb;95(2):215-22. doi: 10.1177/0022034515611876. Epub 2015 Oct 23.
4 Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria-induced NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation J Biol Chem. 2003 Jun 27;278(26):23851-60. doi: 10.1074/jbc.M300075200. Epub 2003 Apr 2.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Tang and Dr. Zhang.